Molecular Matchmakers

Molecular matchmakers are a class of proteins that use the energy released from the hydrolysis of adenosine triphosphate to cause a conformational change in one or both components of a DNA binding protein pair to promote formation of a metastable DNA-protein complex. After matchmaking the matchmaker...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1993-03, Vol.259 (5100), p.1415-1420
Main Authors: Sancar, Aziz, Hearst, John E.
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Adenosine triphosphatases
ATP
ATPases
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
Cellular biology
CHEMICAL REACTIONS
COMPLEXES
CONFORMATIONAL CHANGES
DECOMPOSITION
Deoxyribonucleic acid
DNA
DNA - genetics
DNA - metabolism
DNA binding proteins
DNA damage
DNA mismatch repair
DNA Repair
DNA Replication
DNA, Bacterial - genetics
DNA, Bacterial - metabolism
DNA-Binding Proteins - metabolism
ENERGY
Escherichia coli - genetics
Escherichia coli - metabolism
Fundamental and applied biological sciences. Psychology
HYDROLYSIS
INTERACTIONS
Kinetics
LYSIS
Matchmaking
Miscellaneous
Models, Genetic
Molecular and cellular biology
Molecular Biology
Molecular genetics
NUCLEIC ACIDS
NUCLEOTIDES
ORGANIC COMPOUNDS
Protein Binding
PROTEINS
RECOMBINATION
Recombination, Genetic
REPAIR
SOLVOLYSIS 550200 > Biochemistry
SPECIFICITY
T-Phages - genetics
TRANSCRIPTION
Transcription, Genetic
Transposons
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Description
Summary:Molecular matchmakers are a class of proteins that use the energy released from the hydrolysis of adenosine triphosphate to cause a conformational change in one or both components of a DNA binding protein pair to promote formation of a metastable DNA-protein complex. After matchmaking the matchmaker dissociates from the complex, permitting the matched protein to engage in other protein-protein interactions to bring about the effector function. Matchmaking is most commonly used under circumstances that require targeted, high-avidity DNA binding without relying solely on sequence specificity. Molecular matchmaking is an extensively used mechanism in repair, replication, and transcription and most likely in recombination and transposition reactions, too.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8451638