B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black × New Zealand white)F1 mice : effect of total lymphoid irradiation

• Published in: Arthritis and rheumatism 1990-05, Vol.33 (5), p.702-710
• Main Authors: FARINAS, M. C, ADKINS, B, STALL, A. M, WEISSMAN, I, STROBER, S
• Format: Article
• Language: English
• Subjects: AGE DEPENDENCE; ANIMAL CELLS; ANIMALS; B-Lymphocytes - pathology; B-Lymphocytes - physiology; B-Lymphocytes - radiation effects; Biological and medical sciences; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CELL FLOW SYSTEMS; Cell Movement; Cell Separation; CONNECTIVE TISSUE CELLS; Experimental and animal immunopathology. Animal models; Female; Flow Cytometry; Immunohistochemistry; Immunopathology; IRRADIATION; LEUKOCYTES; Lymphatic Irradiation; LYMPHATIC SYSTEM; LYMPHOCYTES; MAMMALS; MATERIALS; Medical sciences; MICE; Mice, Inbred Strains; ORGANS; PHENOTYPE; RADIATION EFFECTS; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT; RODENTS; SOMATIC CELLS; THYMUS; Thymus Gland - pathology; Thymus Gland - radiation effects; VERTEBRATES 560152 > Radiation Effects on Animals-- Animals
• ISSN: 0004-3591; 1529-0131
• DOI: 10.1002/art.1780330513

Thymuses from female (New Zealand black x New Zealand white)F1 [( NZB x NZW]F1), New Zealand black, and New Zealand white mice of different ages were examined by immunohistochemical and flow cytometric analysis. Two-and-a-half-month-old (NZB x NZW)F1 mice showed infiltration of the thymus with B cells, and by 6-8 months of age, showed a disruption of the entire medullary area. More than 80% of the thymic B cells had the phenotypic characteristics of conventional B cells (IgM+, IgD+, Ly-1-). Total lymphoid irradiation induced a marked depletion of medullary B cells and a restoration of the thymic architecture.