Toxicokinetic study of rat intestinal brush border membrane enzymes following in vitro exposure to lead and vanadium

The effect of various concentrations of lead and vanadium on enzyme activity in the cells of the intestinal brush border membrane (BBM) of the rat was investigated. Lead inhibited the activity of all investigated enzymes in a dose related manner, except for that of alkaline phosphatase, demonstratin...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1994-06, Vol.52 (6), p.919-926
Main Authors: GUPTA, K, UPRETI, R. K, KIDWAI, A. M
Format: Article
Language:English
Subjects:
Acetylcholinesterase - metabolism
Alkaline Phosphatase - metabolism
ANIMALS
Biological and medical sciences
BIOLOGICAL EFFECTS
Calcium-Transporting ATPases - metabolism
Chemical and industrial products toxicology. Toxic occupational diseases
DIGESTIVE SYSTEM
ELEMENTS
ENZYMES
gamma-Glutamyltransferase - metabolism
GASTROINTESTINAL TRACT
Intestines - drug effects
Intestines - enzymology
Intestines - ultrastructure
LEAD
Lead - pharmacokinetics
Lead - toxicity
Male
MAMMALS
Medical sciences
METALS
Metals and various inorganic compounds
Microvilli - drug effects
Microvilli - enzymology
ORGANIC COMPOUNDS
PROTEINS
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RATS
RODENTS
Toxicology
TRANSITION ELEMENTS
VANADIUM
Vanadium - pharmacokinetics
Vanadium - toxicity
VERTEBRATES 560300 > Chemicals Metabolism & Toxicology
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Summary:The effect of various concentrations of lead and vanadium on enzyme activity in the cells of the intestinal brush border membrane (BBM) of the rat was investigated. Lead inhibited the activity of all investigated enzymes in a dose related manner, except for that of alkaline phosphatase, demonstrating the disruption of calcium transport. Exposure to vanadium resulted in noncompetitive inhibition of both calcium- and magnesium-ATPase. Partial blockage of enzyme sites by lead and vanadium is postulated.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF00200703