Insensitivity of Tc-99m Pertechnetate for Detecting Metastases of Differentiated Thyroid Carcinoma

To evaluate the use of Tc-99m pertechnetate whole body scanning for the detection of metastases of differentiated thyroid carcinoma, the authors performed sequential Tc-99m pertechnetate and I-131 scans in five patients with known or suspected metastatic thyroid cancer. All five patients had abnorma...

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Bibliographic Details
Published in:Clinical nuclear medicine 1990-01, Vol.15 (1), p.1-4
Main Authors: CAMPBEL, CHRISTINE M, KHAFAGI, FREDERICK A
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnostic imaging
Adenocarcinoma - secondary
Adult
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
Carcinoma, Papillary - diagnostic imaging
Carcinoma, Papillary - secondary
CARCINOMAS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DRUGS
ENDOCRINE GLANDS
Female
GLANDS
HOURS LIVING RADIOISOTOPES
Humans
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
Iodine Radioisotopes
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
Male
METASTASES
Middle Aged
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PATIENTS
PERTECHNETATES
Prospective Studies
RADIOISOTOPES
RADIOLOGY AND NUCLEAR MEDICINE
Radionuclide Imaging
RADIOPHARMACEUTICALS
REFRACTORY METAL COMPOUNDS
SENSITIVITY ANALYSIS
Sensitivity and Specificity
Sodium Pertechnetate Tc 99m
SPECIFICITY
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
THYROID
Thyroid Neoplasms - diagnostic imaging
TRANSITION ELEMENT COMPOUNDS
WHOLE-BODY COUNTING
YEARS LIVING RADIOISOTOPES 550601 > Medicine-- Unsealed Radionuclides in Diagnostics
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Description
Summary:To evaluate the use of Tc-99m pertechnetate whole body scanning for the detection of metastases of differentiated thyroid carcinoma, the authors performed sequential Tc-99m pertechnetate and I-131 scans in five patients with known or suspected metastatic thyroid cancer. All five patients had abnormal I-131 uptake, but only two patients had abnormal Tc-99m pertechnetate uptake. A total of 33 abnormal foci were located with I-131; Tc-99m pertechnetate detected only 3 of these foci, and did not demonstrate any foci that were not apparent with I-131. Despite the theoretical advantages of Tc-99m pertechnetate, it cannot be recommended as a substitute for I-131 for locating thyroid cancer metastases.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199001000-00001