Fetotoxic effects of exposure to the vapor of organic solvents from a synthetic adhesive in mice

Female mice were exposed throughout their pregnancies to organic solvents vaporized from a commercial adhesive, and malformations of fetuses were examined on day 17 of the pregnancies. In mice exposed to 27.0 g of the adhesive, which was the highest exposure concentration that did not result in the...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1994-09, Vol.53 (3), p.471-478
Main Authors: TACHI, N, SHIMOTORI, S, FUJISE, H, SONOKI, S, NARUSE, M, ITANI, T, AOYAMA, M
Format: Article
Language:English
Subjects:
ADHESIVES
Adhesives - chemical synthesis
Adhesives - toxicity
ANIMALS
Atmosphere Exposure Chambers
Biological and medical sciences
BIOLOGICAL EFFECTS
Body Weight - drug effects
Chemical and industrial products toxicology. Toxic occupational diseases
EVAPORATION
Female
FETUSES
MAMMALS
Medical sciences
MICE
ONTOGENESIS
ORGANIC SOLVENTS
PHASE TRANSFORMATIONS
Placenta - drug effects
Pregnancy
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RODENTS
SOLVENTS
Solvents - administration & dosage
Solvents - toxicity
Teratogens - toxicity
Toxicology
VERTEBRATES 560300 > Chemicals Metabolism & Toxicology
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Description
Summary:Female mice were exposed throughout their pregnancies to organic solvents vaporized from a commercial adhesive, and malformations of fetuses were examined on day 17 of the pregnancies. In mice exposed to 27.0 g of the adhesive, which was the highest exposure concentration that did not result in the death of all subjects, the number of implantation sites was reduced 50% compared to other exposed groups and controls. The average number of fetuses was also reduced significantly. Fetal growth was suppressed in a dose-dependent manner, but no external malformations were observed in the fetuses.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF00197242