Mapping of the genes for human endoplasmic reticular heat shock proteins gp96/grp94

The murine tumor rejection antigen gp96 (TRA1, mapped to mouse chromosome 10) is a member of the heat shock protein family. Using a fragment of the murine gp96 cDNA as a probe, three gp96-related human genes have been isolated and structurally characterized. They have been mapped to human chromosome...

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Bibliographic Details
Published in:Somatic cell and molecular genetics 1993-01, Vol.19:1
Main Authors: Maki, R.G., Srivastava, P.K., Eddy, R.L. Jr, Byers, M., Shows, T.B.
Format: Article
Language:English
Subjects:
ANTIGENS
BASIC BIOLOGICAL SCIENCES
CELL CONSTITUENTS
CHROMOSOMES
ENDOPLASMIC RETICULUM
ENERGY
GENETIC MAPPING
HEAT
HUMAN CHROMOSOMES
MAPPING
ORGANIC COMPOUNDS 550400 > Genetics
PROTEINS
THERMAL SHOCK
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Summary:The murine tumor rejection antigen gp96 (TRA1, mapped to mouse chromosome 10) is a member of the heat shock protein family. Using a fragment of the murine gp96 cDNA as a probe, three gp96-related human genes have been isolated and structurally characterized. They have been mapped to human chromosomes 1 (p22), 12 (q24.2 [r arrow] q24.3), and 15 (q25 [r arrow] q26) by Southern blot hybridization and in situ hybridization of gene-specific probes. Only one of the genes, designated TRA1 (human chromosome 12) is a coding gene; the other genes (TRA1P1 and TRAP2) appear to be independently derived, processed pseudogenes. 35 refs., 3 figs., 1 tab.
ISSN:0740-7750
1572-9931
DOI:10.1007/BF01233956