Assessment of human exposure to atrazine through the determination of free atrazine in urine

Human exposure to atrazine was studied in four subjects working in an atrazine production plant. Each subject wore skin pads around their necks and used hand washing to assess the amount of atrazine in airborne dust. Urine samples were taken before, during, and after the workshifts and analyzed for...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1990-01, Vol.44 (1), p.1-7
Main Authors: Catenacci, G. (University of Pavia, Pavia, Italy), Maroni, M, Cottica, D, Pozzoli, L
Format: Article
Language:English
Subjects:
560300 - Chemicals Metabolism & Toxicology
ABSORPTION
Adult
Air - analysis
AIR SAMPLERS
ANALISIS
ANALYSE
ANALYSIS
Atrazine - poisoning
Atrazine - urine
AZINES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL ANALYSIS
CLEARANCE
EXCRECION
EXCRETION
HERBICIDAS
HERBICIDE
HERBICIDES
HETEROCYCLIC COMPOUNDS
Humans
Male
MATERIALS
METABOLISM
Middle Aged
Occupational Diseases - chemically induced
Occupational Diseases - urine
OCCUPATIONAL EXPOSURE
OCCUPATIONAL HAZARDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORINA
PERSONNEL
QUANTITATIVE CHEMICAL ANALYSIS
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RESIDU
RESIDUES
RESIDUOS
RIESGOS OCUPACIONALES
RISQUE PROFESSIONNEL
SAMPLERS
Skin - drug effects
SKIN ABSORPTION
TRIAZINES
UPTAKE
URINE
WASTES
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Description
Summary:Human exposure to atrazine was studied in four subjects working in an atrazine production plant. Each subject wore skin pads around their necks and used hand washing to assess the amount of atrazine in airborne dust. Urine samples were taken before, during, and after the workshifts and analyzed for free atrazine. Air atrazine concentrations varied from 0.07-0.53 mg/m super(3). Skin deposition ranged from 4.11-10.66 mg/hr. Urinary excretion patterns were consistent with exposure. The small amounts of unchanged atrazine found in urine only account for a fraction of the total absorbed dose. This method is best suited for qualitative analyses and further work should be completed to develop monitoring procedures based on atrazine metabolites in urine.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF01702354