METHODS FOR ANALYZING COMBINED DATA FROM STUDIES OF WORKERS EXPOSED TO LOW DOSES OF RADIATION

Epidemiologic studies of workers exposed occupationally to protracted low doses of radiation provide a direct assessment of health effects resulting from such exposure and thus supplement information provided by studies of populations exposed at high doses of radiation and high dose rates. Analyses...

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Bibliographic Details
Published in:American journal of epidemiology 1990-05, Vol.131 (5), p.917-927
Main Authors: GILBERT, ETHEL S., FRY, SHIRLEY A., WIGGS, LAURIE D., VOELZ, GEORGE L., CRAGLE, DONNA L., PETERSEN, GERALD R.
Format: Article
Language:English
Subjects:
560151 - Radiation Effects on Animals- Man
Biological and medical sciences
Biological effects of radiation
Colorado - epidemiology
DATA ANALYSIS
DOSES
Epidemiologic Methods
EPIDEMIOLOGY
Fundamental and applied biological sciences. Psychology
HAZARDS
HEALTH HAZARDS
Humans
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
Male
Maximum Allowable Concentration
MAXIMUM PERMISSIBLE EXPOSURE
mortality
NATIONAL ORGANIZATIONS
Neoplasms, Radiation-Induced - epidemiology
Neoplasms, Radiation-Induced - etiology
OAK RIDGE RESERVATION
OCCUPATIONAL DISEASES
Occupational Diseases - epidemiology
Occupational Diseases - etiology
OCCUPATIONAL EXPOSURE
ORNL
PERSONNEL
radiation
Radiation Dosage
RADIATION DOSES
RADIATION HAZARDS
RADIATION PROTECTION
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RADIATIONS
Radiocontamination
RISK ASSESSMENT
Risk Factors
ROCKY FLATS PLANT
SAFETY STANDARDS
statistics
Tennessee - epidemiology
Time Factors
Tissues, organs and organisms biophysics
US AEC
US DOE
US ERDA
US ORGANIZATIONS
Washington - epidemiology
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Description
Summary:Epidemiologic studies of workers exposed occupationally to protracted low doses of radiation provide a direct assessment of health effects resulting from such exposure and thus supplement information provided by studies of populations exposed at high doses of radiation and high dose rates. Analyses based on combined data from several studies can be expected to provide a more thorough assessment of low dose occupational studies and more precise risk estimates than can be obtained from any single study. Statistical methods for conducting such combined analyses are discussed, and different approaches, such as basing analyses on various levels of aggregation of exposure data, are compared and evaluated. Emphasis is given to methods for obtaining risk estimates and confidence limits that can be appropriately compared with estimates that form the basis for current radiation protection standards; these estimates have been obtained through extrapolation from high dose data. Methods are illustrated using combined data on workers at three US Department of Energy facilities: the Hanford Site, Richland, Washington; the Oak Ridge National Laboratory, Oak Ridge, Tennessee; and the Rocky Flats Nuclear Weapons Plant, Denver, Colorado.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a115581