Iodide and albumin kinetics in normal canine wrists and knees

The clearance rates of free iodide and of radioiodinated serum albumin were measured in the knee and wrist joints of 9 normal adult dogs. Iodide clearance from the knee was 3 times greater than that from the wrist. In contrast, radioiodinated serum albumin clearance from the knee was only slightly g...

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Bibliographic Details
Published in:Arthritis and rheumatism 1990-01, Vol.33 (1), p.73-79
Main Authors: Simkin, Peter A., Benedict, Richard S.
Format: Article
Language:English
Subjects:
550501 - Metabolism- Tracer Techniques
ALBUMINS
ANIMALS
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
BODY
BODY AREAS
BONE JOINTS
Carpus, Animal - metabolism
CLEARANCE
DOGS
Female
Forelimb - metabolism
Fundamental and applied biological sciences. Psychology
HALIDES
HALOGEN COMPOUNDS
IODIDES
Iodides - pharmacokinetics
IODINE COMPOUNDS
IODINE ISOTOPES
Iodine Radioisotopes
ISOTOPE APPLICATIONS
ISOTOPES
Knee Joint - metabolism
LEGS
LIMBS
Male
MAMMALS
MATHEMATICS
METABOLISM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REGRESSION ANALYSIS
Serum Albumin - pharmacokinetics
SKELETON
Skeleton and joints
STATISTICS
Time Factors
TRACER TECHNIQUES
VERTEBRATES
Vertebrates: osteoarticular system, musculoskeletal system
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Description
Summary:The clearance rates of free iodide and of radioiodinated serum albumin were measured in the knee and wrist joints of 9 normal adult dogs. Iodide clearance from the knee was 3 times greater than that from the wrist. In contrast, radioiodinated serum albumin clearance from the knee was only slightly greater than that from the wrist. Interpreted as respective indices of effective synovial plasma flow and lymphatic drainage, these values indicate that the filtration fraction is normally greater in microvessels of the wrist than in those of the knee. These findings complement the results of companion studies of Starling forces that indicate a higher pressure microvascular bed in the wrist than in the knee.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780330109