Evaluation of ultrastructural hepatic response to environmental toxicants in wild cotton rats (Sigmodon hispidus)

The effect of PCB exposure on the hepatic structure of wild cotton rats was studied at a PCB-contaminated industrial site in Oklahoma. Dissections revealed that the contaminated rats had lesions only on the liver. In comparison with uncontaminated rats, the contaminated rats had high liver-weight:bo...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1991-08, Vol.47 (2), p.321-328
Main Authors: ELANGBAM, C. S, QUALLS, C. W, CONFER, A. W
Format: Article
Language:English
Subjects:
560300 - Chemicals Metabolism & Toxicology
ANIMAL CELLS
ANIMALS
AROMATICS
BIOCHEMISTRY
Biological and medical sciences
BIOLOGICAL EFFECTS
Body Weight - drug effects
Chemical and Drug Induced Liver Injury - enzymology
Chemical and Drug Induced Liver Injury - pathology
CHEMISTRY
CHLORINATED AROMATIC HYDROCARBONS
Cytochrome P-450 Enzyme System - metabolism
Environmental Pollutants - toxicity
Environmental pollutants toxicology
ENZYMES
HALOGENATED AROMATIC HYDROCARBONS
Liver - enzymology
Liver - pathology
Liver - ultrastructure
LIVER CELLS
MAMMALS
Medical sciences
MIXED-FUNCTION OXIDASES
MORPHOLOGICAL CHANGES
Oklahoma
Organ Size - drug effects
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXIDOREDUCTASES
OXYGENASES
Polychlorinated Biphenyls - toxicity
PROTEINS
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RATS
RODENTS
Sigmodontinae
SOMATIC CELLS
Toxicology
ULTRASTRUCTURAL CHANGES
VERTEBRATES
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Summary:The effect of PCB exposure on the hepatic structure of wild cotton rats was studied at a PCB-contaminated industrial site in Oklahoma. Dissections revealed that the contaminated rats had lesions only on the liver. In comparison with uncontaminated rats, the contaminated rats had high liver-weight:body-weight and liver-volume:body-volume ratios; these increases were caused by elevated total hepatic cytochrome P-450 activity levels. The ultrastructural liver evaluation of wild rats, when combined with additional hepatic analyses, appears to be a practical method of environmental monitoring.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF01688659