Photonic Crystal Carbohydrate Sensors:  Low Ionic Strength Sugar Sensing

We developed a carbohydrate sensing material, which consists of a crystalline colloidal array (CCA) incorporated into a polyacrylamide hydrogel (PCCA) with pendent boronic acid groups. The embedded CCA diffracts visible light, and the PCCA diffraction wavelength reports on the hydrogel volume. This...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2003-03, Vol.125 (11), p.3322-3329
Main Authors: Asher, Sanford A, Alexeev, Vladimir L, Goponenko, Alexander V, Sharma, Anjal C, Lednev, Igor K, Wilcox, Craig S, Finegold, David N
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Analytical chemistry
Biosensing Techniques - methods
Boronic Acids - chemistry
CARBOHYDRATES
CHEMISTRY
ENVIRONMENTAL SCIENCES
Exact sciences and technology
General, instrumentation
Glucose - analysis
Hydrogels - chemistry
INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY
Osmolar Concentration
SACCHAROSE
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Summary:We developed a carbohydrate sensing material, which consists of a crystalline colloidal array (CCA) incorporated into a polyacrylamide hydrogel (PCCA) with pendent boronic acid groups. The embedded CCA diffracts visible light, and the PCCA diffraction wavelength reports on the hydrogel volume. This boronic acid PCCA responds to species containing vicinal cis diols such as carbohydrates. This PCCA photonic crystal sensing material responds to glucose in low ionic strength aqueous solutions by swelling and red shifting its diffraction as the glucose concentration increases. The hydrogel swelling results from a Donnan potential due to formation of boronate anion; the boronic acid pK a decreases upon glucose binding. This sensing material responds to glucose and other sugars at
ISSN:0002-7863
1520-5126
DOI:10.1021/ja021037h