The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36

Fatty acid translocase (FAT)/CD36 has been associated with diverse normal and pathologic processes. These include scavenger receptor functions (uptake of apoptotic cells and modified lipid), lipid metabolism and fatty acid transport, adhesion, angiogenesis, modulation of inflammation, transforming g...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2002-10, Vol.239 (1-2), p.193-197
Main Authors: Febbraio, M, Guy, E, Coburn, C, Knapp, Jr, F F, Beets, A L, Abumrad, N A, Silverstein, R L
Format: Article
Language:English
Subjects:
Adipocytes - metabolism
Animals
BASIC BIOLOGICAL SCIENCES
CARBOXYLIC ACIDS
CD36 Antigens - genetics
CD36 Antigens - metabolism
Disease Models, Animal
ENZYMES
Fatty acids
Fatty Acids - metabolism
GENETICS
Humans
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
NUTRITIONAL DEFICIENCY
Organic Anion Transporters - genetics
Organic Anion Transporters - metabolism
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Summary:Fatty acid translocase (FAT)/CD36 has been associated with diverse normal and pathologic processes. These include scavenger receptor functions (uptake of apoptotic cells and modified lipid), lipid metabolism and fatty acid transport, adhesion, angiogenesis, modulation of inflammation, transforming growth factor-beta activation, atherosclerosis, diabetes and cardiomyopathy. Although CD36 was identified more than 25 years ago, it is only with the advent of recent genetic technology that in vivo evidence has emerged for its physiologic and pathologic relevance. As these in vivo studies are expanded, we will gain further insight into the mechanism(s) by which CD36 transmits a cellular signal, and this will allow the design of specific therapeutics that impact on a particular function of CD36.
ISSN:0300-8177
1573-4919
DOI:10.1023/a:1020515210972