Determination of the Tissue Distribution and Excretion by Accelerator Mass Spectrometry of the Nonadecapeptide 14C-Moli1901 in Beagle dogs after Intratracheal Instillation

Administration of {sup 14}C-Moli1901 (duramycin, 2622U90), a 19 amino acid polycyclic peptide by intratracheal instillation (approximately 100 {micro}g) into the left cranial lobe of the lung of beagle dogs resulted in retention of 64% of the dose in the left cranial lobe for up to 28 days. In this...

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Bibliographic Details
Published in:Chemico-biological interactions 2004-07, Vol.155 (1-2)
Main Authors: Rickert, D E, Dingley, K H, Ubick, E, Dix, K J, Molina, L
Format: Article
Language:English
Subjects:
ACCELERATORS
AMINO ACIDS
BASIC BIOLOGICAL SCIENCES
BEAGLES
BILE
BLOOD
BRAIN
EXCRETION
FECES
FIBROSIS
INHALATION
LIVER
LUNGS
MASS SPECTROSCOPY
PARTICLE ACCELERATORS
PATIENTS
PEPTIDES
PLASMA
RETENTION
SPLEEN
TISSUE DISTRIBUTION
URINE
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Summary:Administration of {sup 14}C-Moli1901 (duramycin, 2622U90), a 19 amino acid polycyclic peptide by intratracheal instillation (approximately 100 {micro}g) into the left cranial lobe of the lung of beagle dogs resulted in retention of 64% of the dose in the left cranial lobe for up to 28 days. In this study, we used accelerator mass spectrometry (AMS) to quantify Moli901 following administration of only 0.045 {micro}Ci of {sup 14}C-Moli901 per dog. Limits of quantitation of AMS were 0.03 (urine) to 0.3 (feces) ng equiv. Moli1901/g. Whole blood and plasma concentrations of {sup 14}C were
ISSN:0009-2797
1872-7786