Nanoscale Morphology of Polyanhydride Copolymers

The microphase separation in polyanhydride random copolymers composed of 1,6-bis(p-carboxyphenoxy)hexane and sebacic acid is described. Though the copolymers are random, the monomers are sufficiently long and the segment−segment interaction parameter is sufficiently high to promote microphase separa...

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Bibliographic Details
Published in:Macromolecules 2005-10, Vol.38 (20), p.8468-8472
Main Authors: Kipper, Matt J, Hou, Sheng-Shu, Seifert, Soenke, Thiyagarajan, P, Schmidt-Rohr, Klaus, Narasimhan, Balaji
Format: Article
Language:English
Subjects:
advanced photon source
ANHYDRIDES
Applied sciences
COPOLYMERS
Exact sciences and technology
MATERIALS SCIENCE
NANOSTRUCTURES
Organic polymers
Physicochemistry of polymers
Properties and characterization
Structure, morphology and analysis
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Summary:The microphase separation in polyanhydride random copolymers composed of 1,6-bis(p-carboxyphenoxy)hexane and sebacic acid is described. Though the copolymers are random, the monomers are sufficiently long and the segment−segment interaction parameter is sufficiently high to promote microphase separation when the copolymer is rich in one component. Solid-state NMR spin diffusion experiments and synchrotron small-angle X-ray scattering are used to discern the length scales of the microphase separation. Both techniques reveal a nanostructure with domain sizes less than 25 Å. This nanostructure is compared to approximate calculations of chain dimensions based on a random coil model and discussed in the context of the rational design of these materials for drug delivery applications.
ISSN:0024-9297
1520-5835
DOI:10.1021/ma051267r