Surfaces of Fluorinated Pyridinium Block Copolymers with Enhanced Antibacterial Activity

Polystyrene-b-poly(4-vinylpyridine) copolymers were quaternized with 1-bromohexane and 6-perfluorooctyl-1-bromohexane. Surfaces prepared from these polymers were characterized by contact angle measurements, near-edge X-ray absorption fine structure spectroscopy and X-ray photoelectron spectroscopy....

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Bibliographic Details
Published in:Langmuir 2006-12, Vol.22 (26), p.11255-11266
Main Authors: Krishnan, Sitaraman, Ward, Rebekah J, Hexemer, Alexander, Sohn, Karen E, Lee, Kristen L, Angert, Esther R, Fischer, Daniel A, Kramer, Edward J, Ober, Christopher K
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
BACTERIA
BASIC BIOLOGICAL SCIENCES
Chemistry
COPOLYMERS
Escherichia coli - growth & development
Exact sciences and technology
Fluorocarbons - chemistry
FUNGICIDES
General and physical chemistry
Hydrocarbons, Halogenated - chemistry
national synchrotron light source
ORGANIC BROMINE COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
POLYSTYRENE
Polystyrenes - chemistry
POLYVINYLS
Polyvinyls - chemistry
PYRIDINE
Pyridines - chemistry
Spectrometry, X-Ray Emission - methods
Staphylococcus aureus
SURFACE PROPERTIES
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Summary:Polystyrene-b-poly(4-vinylpyridine) copolymers were quaternized with 1-bromohexane and 6-perfluorooctyl-1-bromohexane. Surfaces prepared from these polymers were characterized by contact angle measurements, near-edge X-ray absorption fine structure spectroscopy and X-ray photoelectron spectroscopy. The fluorinated pyridinium surfaces showed enhanced antibacterial activity compared to their nonfluorinated counterparts. Even a polymer with a relatively low molecular weight pyridinium block showed high antimicrobial activity. The bactericidal effect was found to be related to the molecular composition and organization in the top 2−3 nm of the surface and increased with increasing hydrophilicity and pyridinium concentration of the surface.
ISSN:0743-7463
1520-5827
DOI:10.1021/la061384v