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Review and evaluation of updated research on the health effects associated with low-dose ionising radiation
While radiation health risks at low doses have traditionally been estimated from high-dose studies, we have reviewed recent literature and concluded that the mechanisms of action for many biological endpoints may be different at low doses from those observed at high doses; that acute doses
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| Published in: | Radiation protection dosimetry 2010-07, Vol.140 (2), p.103-136 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c350t-64a271c5aa534991d0bc4c8b64fb76549959c9affea16268a779691961c20afc3 |
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| cites | cdi_FETCH-LOGICAL-c350t-64a271c5aa534991d0bc4c8b64fb76549959c9affea16268a779691961c20afc3 |
| container_end_page | 136 |
| container_issue | 2 |
| container_start_page | 103 |
| container_title | Radiation protection dosimetry |
| container_volume | 140 |
| creator | Dauer, Lawrence T. Brooks, Antone L. Hoel, David G. Morgan, William F. Stram, Daniel Tran, Phung |
| description | While radiation health risks at low doses have traditionally been estimated from high-dose studies, we have reviewed recent literature and concluded that the mechanisms of action for many biological endpoints may be different at low doses from those observed at high doses; that acute doses |
| doi_str_mv | 10.1093/rpd/ncq141 |
| format | article |
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(PNNL), Richland, WA (United States)</creatorcontrib><title>Review and evaluation of updated research on the health effects associated with low-dose ionising radiation</title><title>Radiation protection dosimetry</title><addtitle>Radiat Prot Dosimetry</addtitle><description>While radiation health risks at low doses have traditionally been estimated from high-dose studies, we have reviewed recent literature and concluded that the mechanisms of action for many biological endpoints may be different at low doses from those observed at high doses; that acute doses <100 mSv may be too small to allow epidemiological detection of excess cancers given the background of naturally occurring cancers; that low-dose radiation research should use holistic approaches such as systems-based methods to develop models that define the shape of the dose–response relationship; and that these results should be combined with the latest epidemiology to produce a comprehensive understanding of radiation effects that addresses both damage, likely with a linear effect, and response, possibly with non-linear consequences. 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| identifier | ISSN: 0144-8420 |
| ispartof | Radiation protection dosimetry, 2010-07, Vol.140 (2), p.103-136 |
| issn | 0144-8420 1742-3406 |
| language | eng |
| recordid | cdi_osti_scitechconnect_984205 |
| source | Oxford Journals Online |
| subjects | ATOMIC-BOMB SURVIVORS DETECTION DOSE-RESPONSE RELATIONSHIPS EVALUATION Humans INDUCED GENOMIC INSTABILITY IONIZING RADIATIONS LOW-LET RADIATION Neoplasms - radiotherapy NORMAL HUMAN FIBROBLASTS NUCLEAR-POWER-PLANTS Occupational Exposure - adverse effects Radiation Dosage RADIATION EFFECTS Radiation Injuries - etiology RADIATION PROTECTION AND DOSIMETRY Radiation, Ionizing RADIATIONS RADIOBIOLOGY RAT LUNG IRRADIATION SHAPE SOLID CANCER INCIDENCE TECHA RIVER POPULATION TRANSFORMATION IN-VITRO US RADIOLOGIC TECHNOLOGISTS |
| title | Review and evaluation of updated research on the health effects associated with low-dose ionising radiation |
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