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Dual-doped thermographic phosphor particles as surrogates for GFP-labelled cells in tests of cytometric neurocatheters
We investigated the laser-induced fluorescence of particles of a compound thermographic phosphor La2O2S:Eu (1%) and Gd2O2S:Eu (1%), to see if they can serve as a surrogate for cells transfected with the green fluorescent protein, in tests of neurocatheters used for intraparenchymal cell delivery. At...
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Published in: | Journal of applied physics 2010-01, Vol.107 (6) |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | We investigated the laser-induced fluorescence of particles of a compound thermographic phosphor La2O2S:Eu (1%) and Gd2O2S:Eu (1%), to see if they can serve as a surrogate for cells transfected with the green fluorescent protein, in tests of neurocatheters used for intraparenchymal cell delivery. At an excitation wavelength of 337 nm and a concentration of 2x106 particles ml-1, the resulting slurries produced fluorescence intensities at 625 nm that were within a factor of two of those produced by similar number densities of relevant cells, thus suggesting the utility of this approach. |
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ISSN: | 0021-8979 1089-7550 |
DOI: | 10.1063/1.3359656 |