Regulation of the Transient Outward K+ Current by Ca2+/Calmodulin-Dependent Protein Kinases II in Human Atrial Myocytes

Ca/calmodulin-dependent protein kinases II (CaMKII) have important functions in regulating cardiac excitability and contractility. In the present study, we examined whether CaMKII regulated the transient outward K current (Ito) in whole-cell patch-clamped human atrial myocytes. We found that a speci...

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Bibliographic Details
Published in:Circulation research 1999-10, Vol.85 (9), p.810-819
Main Authors: Tessier, Sophie, Karczewski, Peter, Krause, Ernst-Georg, Pansard, Yves, Acar, Christophe, Lang-Lazdunski, Michel, Mercadier, Jean-Jacques, Hatem, Stéphane N
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Heart
Medical sciences
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Summary:Ca/calmodulin-dependent protein kinases II (CaMKII) have important functions in regulating cardiac excitability and contractility. In the present study, we examined whether CaMKII regulated the transient outward K current (Ito) in whole-cell patch-clamped human atrial myocytes. We found that a specific CaMKII inhibitor, KN-93 (20 μmol/L), but not its inactive analog, KN-92, accelerated the inactivation of Ito (τfast66.9±4.4 versus 43.0±4.4 ms, n=35; P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.85.9.810