Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta -agonist therapy

Cardiovascular Research Institute and Departments of Medicine, Anesthesia, and Physiology, University of California, San Francisco, California 94143-0130 Although keratinocyte growth factor (KGF) protects against experimental acute lung injury, the mechanisms for the protective effect are incomplete...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 1999-11, Vol.87 (5), p.1852-1860
Main Authors: Wang, Yibing, Folkesson, Hans G, Jayr, Christian, Ware, Lorraine B, Matthay, Michael A
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - pharmacology
Air breathing
Amiloride - pharmacology
Anatomy & physiology
Animals
Biological and medical sciences
Blotting, Northern
Body Fluids - physiology
Diuretics - pharmacology
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Epithelium - drug effects
Epithelium - metabolism
Fibroblast Growth Factor 10
Fibroblast Growth Factor 7
Fibroblast Growth Factors
Fundamental and applied biological sciences. Psychology
Growth Substances - pharmacology
Injuries
Lungs
Male
Permeability
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - metabolism
Rats
Rats, Sprague-Dawley
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Sodium Channel Blockers
Sodium Channels - biosynthesis
Terbutaline - pharmacology
Time Factors
Up-Regulation - drug effects
Vertebrates: respiratory system
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Summary:Cardiovascular Research Institute and Departments of Medicine, Anesthesia, and Physiology, University of California, San Francisco, California 94143-0130 Although keratinocyte growth factor (KGF) protects against experimental acute lung injury, the mechanisms for the protective effect are incompletely understood. Therefore, the time-dependent effects of KGF on alveolar epithelial fluid transport were studied in rats 48-240 h after intratracheal administration of KGF (5   mg/kg). There was a marked proliferative response to KGF, measured both by in vivo bromodeoxyuridine staining and by staining with an antibody to a type II cell antigen. In controls, alveolar liquid clearance (ALC) was 23 ± 3%/h. After KGF pretreatment, ALC was significantly increased to 30 ± 2%/h at 48 h, to 39 ± 2%/h at 72 h, and to 36 ± 3%/h at 120 h compared with controls ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.1999.87.5.1852