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Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta -agonist therapy
Cardiovascular Research Institute and Departments of Medicine, Anesthesia, and Physiology, University of California, San Francisco, California 94143-0130 Although keratinocyte growth factor (KGF) protects against experimental acute lung injury, the mechanisms for the protective effect are incomplete...
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| Published in: | Journal of applied physiology (1985) 1999-11, Vol.87 (5), p.1852-1860 |
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| container_end_page | 1860 |
| container_issue | 5 |
| container_start_page | 1852 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 87 |
| creator | Wang, Yibing Folkesson, Hans G Jayr, Christian Ware, Lorraine B Matthay, Michael A |
| description | Cardiovascular Research Institute and Departments of Medicine,
Anesthesia, and Physiology, University of California, San Francisco,
California 94143-0130
Although keratinocyte growth factor (KGF)
protects against experimental acute lung injury, the mechanisms for the
protective effect are incompletely understood. Therefore, the
time-dependent effects of KGF on alveolar epithelial fluid transport
were studied in rats 48-240 h after intratracheal administration
of KGF (5 mg/kg). There was a marked proliferative response to KGF,
measured both by in vivo bromodeoxyuridine staining and by staining
with an antibody to a type II cell antigen. In controls, alveolar
liquid clearance (ALC) was 23 ± 3%/h. After KGF
pretreatment, ALC was significantly increased to 30 ± 2%/h at 48 h, to 39 ± 2%/h at 72 h, and to 36 ± 3%/h at 120 h compared
with controls ( P |
| doi_str_mv | 10.1152/jappl.1999.87.5.1852 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_1214801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>46745315</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-1a3176f1d4248f2eb48d72a98ddb649c6180d11782ffcc6a59c11826cfe4459c3</originalsourceid><addsrcrecordid>eNp1kV-P1CAUxRujccfVb2AMMcb40sqlQOnjZuOsxk18WZ8JpXTKyLQIdLXf3tZO_Jf4RAi_c87lnix7DrgAYOTtUXnvCqjruhBVwQoQjDzIdssTyYFjeJjtRMVwXjFRXWRPYjxiDJQyeJxdAGac8BLvsi9X7t6MTgVkvE29cVY51LnJtigFNUQ_hoS0GlBjULSnySU1mHGKbkaTD-YwOZVMi5oZNWPq0cebPVLDcjdJoVwdxsHGhBbfoPz8NHvUKRfNs_N5mX3ev7u7fp_ffrr5cH11m2sqypSDKqHiHbSUUNER01DRVkTVom0bTmvNQeAWoBKk67TmitUaQBCuO7N8r9blZfZ68_Vh_DqZmOTJRm2c20aXvCZCUE4W8OU_4HGcwrDMJgkhwAALWCC6QTqMMQbTSR_sSYVZApZrE_JnE3JtQopKMrk2schenL2n5mTaP0Tb6hfg1RlQUSvXLdvWNv7mCFCB1_g3G9bbQ__NBiN9P0c7uvEwr8l_RdL_o_vJuTvzPa2aXxLp2678AYgHtD0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222151081</pqid></control><display><type>article</type><title>Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta -agonist therapy</title><source>American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list)</source><source>American Physiological Society Free</source><creator>Wang, Yibing ; Folkesson, Hans G ; Jayr, Christian ; Ware, Lorraine B ; Matthay, Michael A</creator><creatorcontrib>Wang, Yibing ; Folkesson, Hans G ; Jayr, Christian ; Ware, Lorraine B ; Matthay, Michael A</creatorcontrib><description>Cardiovascular Research Institute and Departments of Medicine,
Anesthesia, and Physiology, University of California, San Francisco,
California 94143-0130
Although keratinocyte growth factor (KGF)
protects against experimental acute lung injury, the mechanisms for the
protective effect are incompletely understood. Therefore, the
time-dependent effects of KGF on alveolar epithelial fluid transport
were studied in rats 48-240 h after intratracheal administration
of KGF (5 mg/kg). There was a marked proliferative response to KGF,
measured both by in vivo bromodeoxyuridine staining and by staining
with an antibody to a type II cell antigen. In controls, alveolar
liquid clearance (ALC) was 23 ± 3%/h. After KGF
pretreatment, ALC was significantly increased to 30 ± 2%/h at 48 h, to 39 ± 2%/h at 72 h, and to 36 ± 3%/h at 120 h compared
with controls ( P < 0.05). By 240 h,
ALC had returned to near-control levels (26 ± 2%/h). The increase
in ALC was explained primarily by the proliferation of alveolar type II
cells, since there was a good correlation between the number of
alveolar type II cells and the increase in ALC
( r = 0.92, P = 0.02). The fraction of ALC
inhibited by amiloride was similar in control rats (33%) as in 72-h
KGF-pretreated rats (38%), indicating that there was probably no major
change in the apical pathways for Na uptake in the KGF-pretreated rats at this time point. However, more rapid ALC at 120 h, compared with 48 h after KGF treatment, may be explained by greater maturation of
-epithelial Na channel, since its expression was greater at 120 than
at 48 h, whereas the number of type II cells was the same at these two
time points. -Adrenergic stimulation with terbutaline 72 h after KGF
pretreatment further increased ALC to 50 ± 7%/h ( P < 0.5). In summary, KGF induced a sustained increase
over 120 h in the fluid transport capacity of the alveolar epithelium. This impressive upregulation in fluid transport was further enhanced with -adrenergic agonist therapy, thus providing evidence that two
different treatments can simultaneously increase the fluid transport
capacity of the alveolar epithelium.
keratinocyte growth factor; pulmonary edema; acute lung injury; lung fluid balance; lung fluid clearance</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1999.87.5.1852</identifier><identifier>PMID: 10562630</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adrenergic beta-Agonists - pharmacology ; Air breathing ; Amiloride - pharmacology ; Anatomy & physiology ; Animals ; Biological and medical sciences ; Blotting, Northern ; Body Fluids - physiology ; Diuretics - pharmacology ; Epithelial Cells - drug effects ; Epithelial Cells - metabolism ; Epithelium - drug effects ; Epithelium - metabolism ; Fibroblast Growth Factor 10 ; Fibroblast Growth Factor 7 ; Fibroblast Growth Factors ; Fundamental and applied biological sciences. Psychology ; Growth Substances - pharmacology ; Injuries ; Lungs ; Male ; Permeability ; Pulmonary Alveoli - drug effects ; Pulmonary Alveoli - metabolism ; Rats ; Rats, Sprague-Dawley ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Sodium Channel Blockers ; Sodium Channels - biosynthesis ; Terbutaline - pharmacology ; Time Factors ; Up-Regulation - drug effects ; Vertebrates: respiratory system</subject><ispartof>Journal of applied physiology (1985), 1999-11, Vol.87 (5), p.1852-1860</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Physiological Society Nov 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-1a3176f1d4248f2eb48d72a98ddb649c6180d11782ffcc6a59c11826cfe4459c3</citedby><cites>FETCH-LOGICAL-c483t-1a3176f1d4248f2eb48d72a98ddb649c6180d11782ffcc6a59c11826cfe4459c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1214801$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10562630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yibing</creatorcontrib><creatorcontrib>Folkesson, Hans G</creatorcontrib><creatorcontrib>Jayr, Christian</creatorcontrib><creatorcontrib>Ware, Lorraine B</creatorcontrib><creatorcontrib>Matthay, Michael A</creatorcontrib><title>Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta -agonist therapy</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Cardiovascular Research Institute and Departments of Medicine,
Anesthesia, and Physiology, University of California, San Francisco,
California 94143-0130
Although keratinocyte growth factor (KGF)
protects against experimental acute lung injury, the mechanisms for the
protective effect are incompletely understood. Therefore, the
time-dependent effects of KGF on alveolar epithelial fluid transport
were studied in rats 48-240 h after intratracheal administration
of KGF (5 mg/kg). There was a marked proliferative response to KGF,
measured both by in vivo bromodeoxyuridine staining and by staining
with an antibody to a type II cell antigen. In controls, alveolar
liquid clearance (ALC) was 23 ± 3%/h. After KGF
pretreatment, ALC was significantly increased to 30 ± 2%/h at 48 h, to 39 ± 2%/h at 72 h, and to 36 ± 3%/h at 120 h compared
with controls ( P < 0.05). By 240 h,
ALC had returned to near-control levels (26 ± 2%/h). The increase
in ALC was explained primarily by the proliferation of alveolar type II
cells, since there was a good correlation between the number of
alveolar type II cells and the increase in ALC
( r = 0.92, P = 0.02). The fraction of ALC
inhibited by amiloride was similar in control rats (33%) as in 72-h
KGF-pretreated rats (38%), indicating that there was probably no major
change in the apical pathways for Na uptake in the KGF-pretreated rats at this time point. However, more rapid ALC at 120 h, compared with 48 h after KGF treatment, may be explained by greater maturation of
-epithelial Na channel, since its expression was greater at 120 than
at 48 h, whereas the number of type II cells was the same at these two
time points. -Adrenergic stimulation with terbutaline 72 h after KGF
pretreatment further increased ALC to 50 ± 7%/h ( P < 0.5). In summary, KGF induced a sustained increase
over 120 h in the fluid transport capacity of the alveolar epithelium. This impressive upregulation in fluid transport was further enhanced with -adrenergic agonist therapy, thus providing evidence that two
different treatments can simultaneously increase the fluid transport
capacity of the alveolar epithelium.
keratinocyte growth factor; pulmonary edema; acute lung injury; lung fluid balance; lung fluid clearance</description><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>Air breathing</subject><subject>Amiloride - pharmacology</subject><subject>Anatomy & physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Body Fluids - physiology</subject><subject>Diuretics - pharmacology</subject><subject>Epithelial Cells - drug effects</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelium - drug effects</subject><subject>Epithelium - metabolism</subject><subject>Fibroblast Growth Factor 10</subject><subject>Fibroblast Growth Factor 7</subject><subject>Fibroblast Growth Factors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Substances - pharmacology</subject><subject>Injuries</subject><subject>Lungs</subject><subject>Male</subject><subject>Permeability</subject><subject>Pulmonary Alveoli - drug effects</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Sodium Channel Blockers</subject><subject>Sodium Channels - biosynthesis</subject><subject>Terbutaline - pharmacology</subject><subject>Time Factors</subject><subject>Up-Regulation - drug effects</subject><subject>Vertebrates: respiratory system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp1kV-P1CAUxRujccfVb2AMMcb40sqlQOnjZuOsxk18WZ8JpXTKyLQIdLXf3tZO_Jf4RAi_c87lnix7DrgAYOTtUXnvCqjruhBVwQoQjDzIdssTyYFjeJjtRMVwXjFRXWRPYjxiDJQyeJxdAGac8BLvsi9X7t6MTgVkvE29cVY51LnJtigFNUQ_hoS0GlBjULSnySU1mHGKbkaTD-YwOZVMi5oZNWPq0cebPVLDcjdJoVwdxsHGhBbfoPz8NHvUKRfNs_N5mX3ev7u7fp_ffrr5cH11m2sqypSDKqHiHbSUUNER01DRVkTVom0bTmvNQeAWoBKk67TmitUaQBCuO7N8r9blZfZ68_Vh_DqZmOTJRm2c20aXvCZCUE4W8OU_4HGcwrDMJgkhwAALWCC6QTqMMQbTSR_sSYVZApZrE_JnE3JtQopKMrk2schenL2n5mTaP0Tb6hfg1RlQUSvXLdvWNv7mCFCB1_g3G9bbQ__NBiN9P0c7uvEwr8l_RdL_o_vJuTvzPa2aXxLp2678AYgHtD0</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Wang, Yibing</creator><creator>Folkesson, Hans G</creator><creator>Jayr, Christian</creator><creator>Ware, Lorraine B</creator><creator>Matthay, Michael A</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta -agonist therapy</title><author>Wang, Yibing ; Folkesson, Hans G ; Jayr, Christian ; Ware, Lorraine B ; Matthay, Michael A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-1a3176f1d4248f2eb48d72a98ddb649c6180d11782ffcc6a59c11826cfe4459c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adrenergic beta-Agonists - pharmacology</topic><topic>Air breathing</topic><topic>Amiloride - pharmacology</topic><topic>Anatomy & physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Body Fluids - physiology</topic><topic>Diuretics - pharmacology</topic><topic>Epithelial Cells - drug effects</topic><topic>Epithelial Cells - metabolism</topic><topic>Epithelium - drug effects</topic><topic>Epithelium - metabolism</topic><topic>Fibroblast Growth Factor 10</topic><topic>Fibroblast Growth Factor 7</topic><topic>Fibroblast Growth Factors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Substances - pharmacology</topic><topic>Injuries</topic><topic>Lungs</topic><topic>Male</topic><topic>Permeability</topic><topic>Pulmonary Alveoli - drug effects</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Sodium Channel Blockers</topic><topic>Sodium Channels - biosynthesis</topic><topic>Terbutaline - pharmacology</topic><topic>Time Factors</topic><topic>Up-Regulation - drug effects</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yibing</creatorcontrib><creatorcontrib>Folkesson, Hans G</creatorcontrib><creatorcontrib>Jayr, Christian</creatorcontrib><creatorcontrib>Ware, Lorraine B</creatorcontrib><creatorcontrib>Matthay, Michael A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yibing</au><au>Folkesson, Hans G</au><au>Jayr, Christian</au><au>Ware, Lorraine B</au><au>Matthay, Michael A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta -agonist therapy</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>87</volume><issue>5</issue><spage>1852</spage><epage>1860</epage><pages>1852-1860</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Cardiovascular Research Institute and Departments of Medicine,
Anesthesia, and Physiology, University of California, San Francisco,
California 94143-0130
Although keratinocyte growth factor (KGF)
protects against experimental acute lung injury, the mechanisms for the
protective effect are incompletely understood. Therefore, the
time-dependent effects of KGF on alveolar epithelial fluid transport
were studied in rats 48-240 h after intratracheal administration
of KGF (5 mg/kg). There was a marked proliferative response to KGF,
measured both by in vivo bromodeoxyuridine staining and by staining
with an antibody to a type II cell antigen. In controls, alveolar
liquid clearance (ALC) was 23 ± 3%/h. After KGF
pretreatment, ALC was significantly increased to 30 ± 2%/h at 48 h, to 39 ± 2%/h at 72 h, and to 36 ± 3%/h at 120 h compared
with controls ( P < 0.05). By 240 h,
ALC had returned to near-control levels (26 ± 2%/h). The increase
in ALC was explained primarily by the proliferation of alveolar type II
cells, since there was a good correlation between the number of
alveolar type II cells and the increase in ALC
( r = 0.92, P = 0.02). The fraction of ALC
inhibited by amiloride was similar in control rats (33%) as in 72-h
KGF-pretreated rats (38%), indicating that there was probably no major
change in the apical pathways for Na uptake in the KGF-pretreated rats at this time point. However, more rapid ALC at 120 h, compared with 48 h after KGF treatment, may be explained by greater maturation of
-epithelial Na channel, since its expression was greater at 120 than
at 48 h, whereas the number of type II cells was the same at these two
time points. -Adrenergic stimulation with terbutaline 72 h after KGF
pretreatment further increased ALC to 50 ± 7%/h ( P < 0.5). In summary, KGF induced a sustained increase
over 120 h in the fluid transport capacity of the alveolar epithelium. This impressive upregulation in fluid transport was further enhanced with -adrenergic agonist therapy, thus providing evidence that two
different treatments can simultaneously increase the fluid transport
capacity of the alveolar epithelium.
keratinocyte growth factor; pulmonary edema; acute lung injury; lung fluid balance; lung fluid clearance</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>10562630</pmid><doi>10.1152/jappl.1999.87.5.1852</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1999-11, Vol.87 (5), p.1852-1860 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_1214801 |
| source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
| subjects | Adrenergic beta-Agonists - pharmacology Air breathing Amiloride - pharmacology Anatomy & physiology Animals Biological and medical sciences Blotting, Northern Body Fluids - physiology Diuretics - pharmacology Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelium - drug effects Epithelium - metabolism Fibroblast Growth Factor 10 Fibroblast Growth Factor 7 Fibroblast Growth Factors Fundamental and applied biological sciences. Psychology Growth Substances - pharmacology Injuries Lungs Male Permeability Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Rats Rats, Sprague-Dawley Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Sodium Channel Blockers Sodium Channels - biosynthesis Terbutaline - pharmacology Time Factors Up-Regulation - drug effects Vertebrates: respiratory system |
| title | Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta -agonist therapy |
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