β2-Microglobulin kinetics in nocturnal haemodialysis

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 2000-01, Vol.15 (1), p.58-64
• Main Authors: Raj, Dominic S. C., Ouwendyk, Michaelene, Francoeur, Robert, Pierratos, Andreas
• Format: Article
• Language: English
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; dialysis; Emergency and intensive care: renal failure. Dialysis management; home dialysis; Intensive care medicine; Medical sciences; nocturnal haemodialysis; β2-microglobulin
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/15.1.58

Background.β2-Microglobulin (β2m) is a major component of dialysis-related amyloidosis. The available therapeutic options do not permit normalization of the serum β2m level. In a cross-over trial, we studied the kinetics of β2m during two different dialytic techniques. Methods. Ten stable, anuric end-stage renal disease patients were studied during two consecutive weeks of three conventional (CHD) and six nocturnal haemodialysis (NHD) sessions. CHD was performed for 4 h three times weekly using a polysulfone dialyser (F80, surface area of 1.8 m2) with a mean blood and dialysate flow rate of 401±91.6 and 514±10.9 ml/min, respectively. The NHD was done with a smaller dialyser (F40, surface area of 0.7 m2) and lower blood (281±17 ml/min) and dialysate flow rates (99±1.2 ml/min) for 8 h, six nights a week. Results. Weekly removal of urea (51.6±24.6 vs 43.1±20.5 g) and creatinine (8501±5204 vs 6319±4134 mg) were comparable with the two modalities of dialysis but the mass of β2m removed was significantly higher with NHD (127±48 vs 585±309 mg, P