Inhibin A, Inhibin B and Activin A in Follicular Fluid of Infertile Women with Tubal Damage, Unexplained Infertility and Endometriosis

Our objectives were to measure and compare concentrations of inhibin A, inhibin B, activin A and oestradiol in the follicular fluid of women with endometriosis, tubal damage and unexplained infertility with oocyte quality and fertilising capacity. Also, to assess whether impaired follicular function...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2000-02, Vol.43 (2), p.61-69
Main Authors: AKANDE, A.V., KEAY, S.D., CAHILL, D.J., WARDLE, P.G., ASSELIN, J., MUTTUKRISHNA, S., GROOME, N.P.
Format: Article
Language:English
Subjects:
activin
activin A
Biological and medical sciences
endometriosis
estradiol
Female genital diseases
follicular fluid
Gynecology. Andrology. Obstetrics
infertility
inhibin
inhibin A
inhibin B
Medical sciences
natural cycles
Non tumoral diseases
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Summary:Our objectives were to measure and compare concentrations of inhibin A, inhibin B, activin A and oestradiol in the follicular fluid of women with endometriosis, tubal damage and unexplained infertility with oocyte quality and fertilising capacity. Also, to assess whether impaired follicular function in women with endometriosis might be related to altered inhibin or activin concentrations and whether this correlated. Follicular fluids were collected from individual follicles during oocyte retrieval for in vitro fertilisation (IVF) in natural cycles. Inhibin A, inhibin B and activin A were measured using two-site enzyme immunoassay, and oestradiol was assayed by fluoro-immunometric method. Follicular fluid inhibin A levels were found to be significantly higher in women with endometriosis. Inhibin A was directly correlated with follicle size. There was no correlation between the levels of inhibin A, inhibin B, activin A and oocyte quality or fertilising capacity in the three groups of women. Follicular fluid concentration of inhibin A is elevated in follicles of women with endometriosis and is positively correlated with follicle maturation. However, we were unable to demonstrate any association between the follicular fluid concentrations of inhibin A, inhibin B, activin A or oestradiol and the quality and fertilisation capacity of oocytes in women with tubal damage, unexplained infertility or endometriosis.
ISSN:1046-7408
8755-8920
1600-0897
DOI:10.1111/j.8755-8920.2000.430201.x