Itraconazole pulse therapy is effective in dermatophyte onychomycosis of the toenail: a double-blind placebo-controlled study

BACKGROUND: Until recently the traditional antifungal agents used to treat onychomycosis of the toenails, griseofulvin and ketoconazole, were generally ineffective and required treatment for a long duration. OBJECTIVE: The objective of the study was to determine the efficacy and safety of itraconazo...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2000, Vol.11 (1), p.33-37
Main Author: Gupta, S Maddin, J Arlette, J-M Giroux, NH Shear, AK
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Itraconazole Onychomycosis Pulse Therapy
Medical sciences
Pharmacology. Drug treatments
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Summary:BACKGROUND: Until recently the traditional antifungal agents used to treat onychomycosis of the toenails, griseofulvin and ketoconazole, were generally ineffective and required treatment for a long duration. OBJECTIVE: The objective of the study was to determine the efficacy and safety of itraconazole (pulse) therapy (200 mg twice daily for 1 week a month for three consecutive months) in onychomycosis of the toenails. METHODS: A randomized, multicenter, placebo-controlled Canadian study was conducted in 200 patients. To allow evaluation for efficacy, the KOH and culture had to be positive at baseline. RESULTS: In the itraconazole (n=78) and placebo (n=74) groups, the mycological cure rates were 61.5% and 28.4%, respectively (p
ISSN:0954-6634
1471-1753
DOI:10.1080/09546630050517658