THE USE OF EBASTINE, A MAST CELL BLOCKER, FOR TREATMENT OF OLIGOZOOSPERMIA

The effect of mast cell blocker (ebastine) on semen quality was evaluated in 15 idiopathic oligozoospermic males. Ten milligrams/day of ebastine was administered orally for 3 months. Nine cases (66.7%) showed definite improvement in the semen quality. The wives of 3 patients (20%) became pregnant wi...

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Bibliographic Details
Published in:Archives of andrology 2000, Vol.44 (2), p.129-132
Main Authors: MATSUKI, S, SASAGAWA, I, SUZUKI, Y, YAZAWA, H, TATENO, T, HASHIMOTO, T, NAKADA, T, SAITO, H, HIROI, M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Butyrophenones - therapeutic use
Genital system. Reproduction
Histamine H1 Antagonists - therapeutic use
Humans
Male
Mast Cell Blocker
Oligozoospermia
Semen Parameter
Mast Cells - drug effects
Medical sciences
Middle Aged
Oligospermia - drug therapy
Pharmacology. Drug treatments
Piperidines - therapeutic use
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Summary:The effect of mast cell blocker (ebastine) on semen quality was evaluated in 15 idiopathic oligozoospermic males. Ten milligrams/day of ebastine was administered orally for 3 months. Nine cases (66.7%) showed definite improvement in the semen quality. The wives of 3 patients (20%) became pregnant within 6 months of the initial treatment. It would appear that mast cell blocker (ebastine) significantly improves semen quality in men with idiopathic oligozoospermia.
ISSN:0955-3002
0148-5016
1362-3095
1521-0375
DOI:10.1080/014850100262290