Evernimicin Binds Exclusively to the 50S Ribosomal Subunit and Inhibits Translation in Cell-Free Systems Derived from both Gram-Positive and Gram-Negative Bacteria

• Published in: Antimicrobial Agents and Chemotherapy 2000-05, Vol.44 (5), p.1121-1126
• Main Authors: MCNICHOLAS, P. M, NAJARIAN, D. J, MANN, P. A, HESK, D, HARE, R. S, SHAW, K. J, BLACK, T. A
• Format: Article
• Language: English
• Subjects: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Avilamycin; Bacterial Proteins - biosynthesis; Bacterial Proteins - genetics; Binding, Competitive - drug effects; Biological and medical sciences; Carbon Radioisotopes; Cell-Free System; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - genetics; evernimicin; Mechanisms of Action: Physiological Effects; Medical sciences; Pharmacology. Drug treatments; Protein Biosynthesis; Protein Biosynthesis - drug effects; Rabbits; ribosomal subunit 50S; Ribosomes; Ribosomes - drug effects; Ribosomes - metabolism; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - genetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.44.5.1121-1126.2000

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