An effective, cosmetically acceptable, novel hydro-gel emollient for the management of dry skin conditions

BACKGROUND : A novel hydro-gel emollient (Doublebase™) has been developed with improved moisturizing effects. OBJECTIVE : To test this novel hydro-gel for its moisturizing effect, for its potential to cause skin irritancy/allergy and for its clinical effectiveness and acceptability in dry skin condi...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2002, Vol.13 (2), p.61-66
Main Authors: Wynne, A, Whitefield, M, Dixon, AJ, Anderson, S
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biological and medical sciences
Child
Dermatitis, Contact - etiology
Dry Skin
Eczema - drug therapy
Eczema / Dermatitis
Emollient
Emollients - administration & dosage
Emollients - adverse effects
Forearm
Humans
Hydro-GEL
Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage
Hydrogel, Polyethylene Glycol Dimethacrylate - adverse effects
Irritants
Male
Medical sciences
Middle Aged
Organic Chemicals
Pharmacology. Drug treatments
Single-Blind Method
Skin - drug effects
Skin Irritancy Tests
Skin, nail, hair, dermoskeleton
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Summary:BACKGROUND : A novel hydro-gel emollient (Doublebase™) has been developed with improved moisturizing effects. OBJECTIVE : To test this novel hydro-gel for its moisturizing effect, for its potential to cause skin irritancy/allergy and for its clinical effectiveness and acceptability in dry skin conditions. METHODS/RESULTS : Skin hydration (corneometry) and trans-epidermal water loss (TEWL) studies with a single application in 18 volunteers confirmed its efficacy ( p < 0.0001) and showed that it was superior to Ultrabase ® and Diprobase ® ( p < 0.001). Skin hydration studies with multiple applications in 12 volunteers also showed that it was superior to Ultrabase and Diprobase ( p < 0.0001). Irritation tests in 74 eczema-prone patients resulted in only one mild reaction, and allergy tests in 99 healthy volunteers elicited no positive reactions. The clinical acceptability and effectiveness of Doublebase was demonstrated in an open study of 78 patients with dry skin conditions. CONCLUSION : Doublebase may be considered a suitable preparation that can be used effectively by most patients with dry skin conditions.
ISSN:0954-6634
1471-1753
DOI:10.1080/095466302317584403