Polymorphisms of the β2-Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure

The β2-adrenergic receptor (β2AR) exists in multiple polymorphic forms with different characteristics. Their relevance to heart failure (HF) physiology is unknown. Cardiopulmonary exercise testing was performed on 232 compensated HF patients with a defined β2AR genotype. Patients with the uncommon I...

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Bibliographic Details
Published in:Circulation research 2000-04, Vol.86 (8), p.834-840
Main Authors: Wagoner, Lynne E, Craft, Laura L, Singh, Balkrishna, Suresh, Damodhar P, Zengel, Paul W, McGuire, Nancy, Abraham, William T, Chenier, Thomas C, Dorn, Gerald W, Liggett, Stephen B
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Human
Medical sciences
Population genetics, reproduction patterns
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Summary:The β2-adrenergic receptor (β2AR) exists in multiple polymorphic forms with different characteristics. Their relevance to heart failure (HF) physiology is unknown. Cardiopulmonary exercise testing was performed on 232 compensated HF patients with a defined β2AR genotype. Patients with the uncommon Ile164 polymorphism had a lower peak o2 (15.0±0.9 mL · kg · min) than did patients with Thr164 (17.9±0.9 mL · kg · min, P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.86.8.834