No association between a promoter dopamine D4 receptor gene variant and schizophrenia

The dopamine D4 receptor has been implicated in the pathogenesis of schizophrenia. An association between a putative functional promoter polymorphism (−521C/T) in the dopamine D4 receptor gene (DRD4) and schizophrenia was recently reported. In the present study, patients with schizophrenia (n = 132)...

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Bibliographic Details
Published in:American journal of medical genetics 2001-08, Vol.105 (6), p.525-528
Main Authors: Jönsson, Erik G., Ivo, Roland, Forslund, Kaj, Mattila-Evenden, Marja, Rylander, Gunnar, Cichon, Sven, Propping, Peter, Nöthen, Markus M., Åsberg, Marie, Sedvall, Göran C.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
association study
Biological and medical sciences
DRD4
Medical genetics
Medical sciences
Mental and behavioral disorders
promoter polymorphism
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
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Summary:The dopamine D4 receptor has been implicated in the pathogenesis of schizophrenia. An association between a putative functional promoter polymorphism (−521C/T) in the dopamine D4 receptor gene (DRD4) and schizophrenia was recently reported. In the present study, patients with schizophrenia (n = 132) and control subjects (n = 388) were analyzed with respect to the DRD4 − 521C/T polymorphism. No significant case control differences emerged. The present results do not support a major role for DRD4 in the etiology of schizophrenia among Caucasians from Sweden. © 2001 Wiley‐Liss, Inc.
ISSN:0148-7299
1096-8628
DOI:10.1002/ajmg.1478