Arginine as an exacerbating factor for glomerulonephritis in rats fed a methionine-threonine-supplemented low casein diet

We previously demonstrated that a methioninethreonine-supplemented low (8.5%) casein diet (8.5CMT) reduced symptoms such as proteinuria in nephritic rats without severe protein malnutrition. In this study, we examined whether or not L-arginine supplementation to 8.5CMT would exacerbate proteinuria a...

Full description

Saved in:
Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2001-05, Vol.65 (5), p.1155-1162
Main Authors: Nihei, T. (Tokyo Univ. of Agriculture and Technology, Fuchu (Japan)), Arai, K, Miura, Y, Yagasaki, K
Format: Article
Language:English
Subjects:
Animals
ARGININE
Arginine - adverse effects
Arginine - antagonists & inhibitors
Biological and medical sciences
Blood Urea Nitrogen
CASEIN
Caseins - administration & dosage
DIET
Dietary Proteins - administration & dosage
Enzyme Inhibitors - pharmacology
GLOMERULONEPHRITIS
Glomerulonephritis - blood
Glomerulonephritis - physiopathology
L-arginine
L-N
Male
Medical sciences
METHIONINE
Methionine - administration & dosage
nephritis
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
NG-Nitroarginine Methyl Ester - pharmacology
nitroarginine methyl ester
PROTEINURIA
RATS
Rats, Wistar
SYMPTOMS
THREONINE
Threonine - administration & dosage
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We previously demonstrated that a methioninethreonine-supplemented low (8.5%) casein diet (8.5CMT) reduced symptoms such as proteinuria in nephritic rats without severe protein malnutrition. In this study, we examined whether or not L-arginine supplementation to 8.5CMT would exacerbate proteinuria and other symptoms in nephritic rats. Male Wistar rats with glomerulonephritis induced by a single intravenous injection of nephrotoxic serum were fed either a 20% casein diet (control), 8.5% casein diet, 8.5CMT, or L-arginine-supplemented 8.5CMT (8.5CMTA) for 16 days. The 8.5CMTA, as compared with the 8.5CMT, aggravated proteinuria and glomerulonephritis. Administration of L-N**G-nitroarginine methyl ester, an inhibitor of nitric oxide synthase, to 8.5CMTA-fed nephritic rats by drinking water for 14 days canceled the adverse effect of L-arginine on proteinuria and histopathological damage in glomeruli. These results suggest that the supplementation of L-arginine makes exacerbation via nitric oxide production in glomerulonephritis.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.65.1155