Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy

Biodegradable poly(DL-lactic acid) (PLA) devices with controlled release of human chorionic gonadotropin (hCG) were fabricated in a 2-mm cylinder form by the melt-pressing technique. The devices fabricated were inserted subcutaneously in the backs of immature rats. It was found that the serum level...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2000-01, Vol.26 (5), p.559-562, Article 559
Main Authors: Okabe, Kazuhiko, Shibata, Yasuhiro, Mashimo, Tooru, Yuasa, Hisako, Yamanaka, Hidetoshi, Asano, Masaharu, Yoshida, Masaru
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Biodegradable device
Biological and medical sciences
Chorionic Gonadotropin - administration & dosage
Chorionic Gonadotropin - therapeutic use
Controlled release
Delayed-Action Preparations
Disease Models, Animal
General pharmacology
Genital system. Reproduction
Gonadotropin
Immunohistochemistry
Infertility, Male - drug therapy
Infertility, Male - veterinary
Male
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Poly(DL-lactic acid)
Rats
Rats, Wistar
Testis
Testis - anatomy & histology
Testosterone - blood
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Summary:Biodegradable poly(DL-lactic acid) (PLA) devices with controlled release of human chorionic gonadotropin (hCG) were fabricated in a 2-mm cylinder form by the melt-pressing technique. The devices fabricated were inserted subcutaneously in the backs of immature rats. It was found that the serum level of testosterone (T) remained constant at approximately 0.7 ng ml for an experimental period of 14 days, resulting in greater Leydig cell production of testosterone. This was also suggested from the results of immunohistochemical observation of the testis and weight changes of prostates, such as the ventral prostates and seminal vesicle.
ISSN:0363-9045
1520-5762
DOI:10.1081/DDC-100101268