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Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy
Biodegradable poly(DL-lactic acid) (PLA) devices with controlled release of human chorionic gonadotropin (hCG) were fabricated in a 2-mm cylinder form by the melt-pressing technique. The devices fabricated were inserted subcutaneously in the backs of immature rats. It was found that the serum level...
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| Published in: | Drug development and industrial pharmacy 2000-01, Vol.26 (5), p.559-562, Article 559 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c415t-c3aaa6906c63b949ecd70a72207eb356e4fdae51e1b0fb382cd3ec83efa10f373 |
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| cites | cdi_FETCH-LOGICAL-c415t-c3aaa6906c63b949ecd70a72207eb356e4fdae51e1b0fb382cd3ec83efa10f373 |
| container_end_page | 562 |
| container_issue | 5 |
| container_start_page | 559 |
| container_title | Drug development and industrial pharmacy |
| container_volume | 26 |
| creator | Okabe, Kazuhiko Shibata, Yasuhiro Mashimo, Tooru Yuasa, Hisako Yamanaka, Hidetoshi Asano, Masaharu Yoshida, Masaru |
| description | Biodegradable poly(DL-lactic acid) (PLA) devices with controlled release of human chorionic gonadotropin (hCG) were fabricated in a 2-mm cylinder form by the melt-pressing technique. The devices fabricated were inserted subcutaneously in the backs of immature rats. It was found that the serum level of testosterone (T) remained constant at approximately 0.7 ng ml for an experimental period of 14 days, resulting in greater Leydig cell production of testosterone. This was also suggested from the results of immunohistochemical observation of the testis and weight changes of prostates, such as the ventral prostates and seminal vesicle. |
| doi_str_mv | 10.1081/DDC-100101268 |
| format | article |
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The devices fabricated were inserted subcutaneously in the backs of immature rats. It was found that the serum level of testosterone (T) remained constant at approximately 0.7 ng ml for an experimental period of 14 days, resulting in greater Leydig cell production of testosterone. This was also suggested from the results of immunohistochemical observation of the testis and weight changes of prostates, such as the ventral prostates and seminal vesicle.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1081/DDC-100101268</identifier><identifier>PMID: 10789069</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Absorbable Implants ; Animals ; Biodegradable device ; Biological and medical sciences ; Chorionic Gonadotropin - administration & dosage ; Chorionic Gonadotropin - therapeutic use ; Controlled release ; Delayed-Action Preparations ; Disease Models, Animal ; General pharmacology ; Genital system. Reproduction ; Gonadotropin ; Immunohistochemistry ; Infertility, Male - drug therapy ; Infertility, Male - veterinary ; Male ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Poly(DL-lactic acid) ; Rats ; Rats, Wistar ; Testis ; Testis - anatomy & histology ; Testosterone - blood</subject><ispartof>Drug development and industrial pharmacy, 2000-01, Vol.26 (5), p.559-562, Article 559</ispartof><rights>2000 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2000</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-c3aaa6906c63b949ecd70a72207eb356e4fdae51e1b0fb382cd3ec83efa10f373</citedby><cites>FETCH-LOGICAL-c415t-c3aaa6906c63b949ecd70a72207eb356e4fdae51e1b0fb382cd3ec83efa10f373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1422124$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10789069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okabe, Kazuhiko</creatorcontrib><creatorcontrib>Shibata, Yasuhiro</creatorcontrib><creatorcontrib>Mashimo, Tooru</creatorcontrib><creatorcontrib>Yuasa, Hisako</creatorcontrib><creatorcontrib>Yamanaka, Hidetoshi</creatorcontrib><creatorcontrib>Asano, Masaharu</creatorcontrib><creatorcontrib>Yoshida, Masaru</creatorcontrib><title>Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>Biodegradable poly(DL-lactic acid) (PLA) devices with controlled release of human chorionic gonadotropin (hCG) were fabricated in a 2-mm cylinder form by the melt-pressing technique. The devices fabricated were inserted subcutaneously in the backs of immature rats. It was found that the serum level of testosterone (T) remained constant at approximately 0.7 ng ml for an experimental period of 14 days, resulting in greater Leydig cell production of testosterone. This was also suggested from the results of immunohistochemical observation of the testis and weight changes of prostates, such as the ventral prostates and seminal vesicle.</description><subject>Absorbable Implants</subject><subject>Animals</subject><subject>Biodegradable device</subject><subject>Biological and medical sciences</subject><subject>Chorionic Gonadotropin - administration & dosage</subject><subject>Chorionic Gonadotropin - therapeutic use</subject><subject>Controlled release</subject><subject>Delayed-Action Preparations</subject><subject>Disease Models, Animal</subject><subject>General pharmacology</subject><subject>Genital system. Reproduction</subject><subject>Gonadotropin</subject><subject>Immunohistochemistry</subject><subject>Infertility, Male - drug therapy</subject><subject>Infertility, Male - veterinary</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Poly(DL-lactic acid)</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Testis</subject><subject>Testis - anatomy & histology</subject><subject>Testosterone - blood</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp1kUtr3DAUhU1paaZpl90WLUp3bvXwczlMmmQgpRDStbmWr7CCLLmSTJg_0d9cJZ4-YVaCy3fOQedk2VtGPzLasE8XF7ucUcoo41XzLNuwktO8rCv-PNtQUYm8pUV5lr0K4T5RvC3Ll9kZo3XT0qrdZD-2w6StDtFD1M4Sp8j1MoElu9H5dNCSXDkLg4vezdqSBx1HAmTnbDoYg0N-iwYhILlcrHyyiI7spwni4pHcQgxEOU-282y0XDOSzRcwSPZWoY_a6HggdyN6mA-vsxcKTMA3x_c8-3b5-W53nd98vdrvtje5LFgZcykAoEo_kJXo26JFOdQUas5pjb0oKyzUAFgyZD1VvWi4HATKRqACRpWoxXn2YfWdvfu-YIjdpINEY8CiW0JXPzZU1G0C8xWU3oXgUXWz1xP4Q8do9zhAlwbofg-Q-HdH46WfcPiLXhtPwPsjAEGCUR6s1OEPV3DOeJEw8V-u1PGpvrSUNifTm1WlbSp9ggfnzdBFOBjnfyWJU9L6H-mIYOIowWN37xZv0xonQn8CMQPFLw</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Okabe, Kazuhiko</creator><creator>Shibata, Yasuhiro</creator><creator>Mashimo, Tooru</creator><creator>Yuasa, Hisako</creator><creator>Yamanaka, Hidetoshi</creator><creator>Asano, Masaharu</creator><creator>Yoshida, Masaru</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy</title><author>Okabe, Kazuhiko ; Shibata, Yasuhiro ; Mashimo, Tooru ; Yuasa, Hisako ; Yamanaka, Hidetoshi ; Asano, Masaharu ; Yoshida, Masaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-c3aaa6906c63b949ecd70a72207eb356e4fdae51e1b0fb382cd3ec83efa10f373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Absorbable Implants</topic><topic>Animals</topic><topic>Biodegradable device</topic><topic>Biological and medical sciences</topic><topic>Chorionic Gonadotropin - administration & dosage</topic><topic>Chorionic Gonadotropin - therapeutic use</topic><topic>Controlled release</topic><topic>Delayed-Action Preparations</topic><topic>Disease Models, Animal</topic><topic>General pharmacology</topic><topic>Genital system. Reproduction</topic><topic>Gonadotropin</topic><topic>Immunohistochemistry</topic><topic>Infertility, Male - drug therapy</topic><topic>Infertility, Male - veterinary</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Poly(DL-lactic acid)</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Testis</topic><topic>Testis - anatomy & histology</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okabe, Kazuhiko</creatorcontrib><creatorcontrib>Shibata, Yasuhiro</creatorcontrib><creatorcontrib>Mashimo, Tooru</creatorcontrib><creatorcontrib>Yuasa, Hisako</creatorcontrib><creatorcontrib>Yamanaka, Hidetoshi</creatorcontrib><creatorcontrib>Asano, Masaharu</creatorcontrib><creatorcontrib>Yoshida, Masaru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okabe, Kazuhiko</au><au>Shibata, Yasuhiro</au><au>Mashimo, Tooru</au><au>Yuasa, Hisako</au><au>Yamanaka, Hidetoshi</au><au>Asano, Masaharu</au><au>Yoshida, Masaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy</atitle><jtitle>Drug development and industrial pharmacy</jtitle><addtitle>Drug Dev Ind Pharm</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>26</volume><issue>5</issue><spage>559</spage><epage>562</epage><pages>559-562</pages><artnum>559</artnum><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Biodegradable poly(DL-lactic acid) (PLA) devices with controlled release of human chorionic gonadotropin (hCG) were fabricated in a 2-mm cylinder form by the melt-pressing technique. The devices fabricated were inserted subcutaneously in the backs of immature rats. It was found that the serum level of testosterone (T) remained constant at approximately 0.7 ng ml for an experimental period of 14 days, resulting in greater Leydig cell production of testosterone. This was also suggested from the results of immunohistochemical observation of the testis and weight changes of prostates, such as the ventral prostates and seminal vesicle.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>10789069</pmid><doi>10.1081/DDC-100101268</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Drug development and industrial pharmacy, 2000-01, Vol.26 (5), p.559-562, Article 559 |
| issn | 0363-9045 1520-5762 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_1422124 |
| source | EBSCOhost Business Source Ultimate; Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Absorbable Implants Animals Biodegradable device Biological and medical sciences Chorionic Gonadotropin - administration & dosage Chorionic Gonadotropin - therapeutic use Controlled release Delayed-Action Preparations Disease Models, Animal General pharmacology Genital system. Reproduction Gonadotropin Immunohistochemistry Infertility, Male - drug therapy Infertility, Male - veterinary Male Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(DL-lactic acid) Rats Rats, Wistar Testis Testis - anatomy & histology Testosterone - blood |
| title | Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy |
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