In-Vitro Activities of Terbinafine, Itraconazole and Amphotericin B Against Aspergillus and Cladosporium species

The in vitro fungicidal and fungistatic activities of terbinafine were compared with those of itraconazole and amphotericin B against Aspergillus (n=63) and Cladosporium (n=21) isolates. The broth macrodilution modification of NCCLS reference method for filamentous fungi (M38-P) was used to assess t...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 2002-12, Vol.14 (6), p.562-567
Main Authors: Kantarcioglu, A.S., Yucel, A.
Format: Article
Language:English
Subjects:
Amphotericin B - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - pharmacology
Aspergillus - drug effects
Biological and medical sciences
Cladosporium - drug effects
Humans
Itraconazole - pharmacology
Medical sciences
Microbial Sensitivity Tests
Naphthalenes - pharmacology
Pharmacology. Drug treatments
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Summary:The in vitro fungicidal and fungistatic activities of terbinafine were compared with those of itraconazole and amphotericin B against Aspergillus (n=63) and Cladosporium (n=21) isolates. The broth macrodilution modification of NCCLS reference method for filamentous fungi (M38-P) was used to assess the minimum inhibitory concentrations (MICs). Our data show that the in vitro activities of terbinafine were comparable to those of itraconazole and amphotericin B against the Aspergillus spp and Cladosporium strains tested. Despite strain-dependent variabilities, in general, itraconazole's activity was similar to that of amphotericin B against strains of Aspergillus and Cladosporium. Our data suggest that terbinafine may be useful in the treatment of Aspergillus and Cladosporium infections.
ISSN:1120-009X
1973-9478
DOI:10.1179/joc.2002.14.6.562