Risk coefficients for childhood cancer after intrauterine irradiation: a review

Purpose: To review the estimates of the risk of childhood cancer per unit dose of radiation received in utero derived from the largest case-control study of obstetric X-ray examinations and to compare them with the childhood cancer risk coefficients obtained from the cohorts of Japanese atomic bomb...

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Bibliographic Details
Published in:International journal of radiation biology 2003-05, Vol.79 (5), p.293-309
Main Authors: Wakeford, R., Little, M. P.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Case-Control Studies
Child
Cohort Studies
Dose-Response Relationship, Radiation
Female
Fetus - radiation effects
Humans
Japan - epidemiology
Leukemia, Radiation-Induced - epidemiology
Leukemia, Radiation-Induced - etiology
Maternal Exposure
Medical sciences
Neoplasms, Radiation-Induced - epidemiology
Neoplasms, Radiation-Induced - etiology
Nuclear Warfare
Pregnancy
Prenatal Exposure Delayed Effects
Radiation Tolerance
Radiography - adverse effects
Risk Factors
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Summary:Purpose: To review the estimates of the risk of childhood cancer per unit dose of radiation received in utero derived from the largest case-control study of obstetric X-ray examinations and to compare them with the childhood cancer risk coefficients obtained from the cohorts of Japanese atomic bomb survivors irradiated either in utero or as young children. Materials and methods: Data from the Oxford Survey of Childhood Cancers (OSCC) case-control study of foetal exposure to diagnostic X-rays and from the cohort studies of the Japanese survivors of the atomic bombings of Hiroshima and Nagasaki were used, together with associated dose estimates. Excess relative risk and excess absolute risk coefficients were compared, fully taking into consideration the various sources of uncertainty. Results: The excess relative risk coefficient for childhood (
ISSN:0955-3002
1362-3095
DOI:10.1080/0955300031000114729