High-resolution 1H and 1H-13C magic angle spinning NMR spectroscopy of rat liver

High‐resolution magic angle spinning (MAS) 1H NMR spectra of small samples (ca. 8 mg) of intact rat liver are reported for the first time. One dimensional spectra reveal a number of large well‐resolved NMR signals mainly from low to medium molecular weight compounds (generally 1,000,000 Daltons) the...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2000-08, Vol.44 (2), p.201-207
Main Authors: Bollard, M.E., Garrod, S., Holmes, E., Lindon, J.C., Humpfer, E., Spraul, M., Nicholson, J.K.
Format: Article
Language:English
Subjects:
1H MAS NMR
1H-13CMAS NMR
Biological and medical sciences
Digestive system
glycogen
HMQC
Investigative techniques, diagnostic techniques (general aspects)
liver
magic angle spinning
Medical sciences
Radiodiagnosis. Nmr imagery. Nmr spectrometry
rat
TOCSY
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Summary:High‐resolution magic angle spinning (MAS) 1H NMR spectra of small samples (ca. 8 mg) of intact rat liver are reported for the first time. One dimensional spectra reveal a number of large well‐resolved NMR signals mainly from low to medium molecular weight compounds (generally 1,000,000 Daltons) there is considerable segmental motion in the glycogen molecules giving long 1H T2 relaxation times. Magn Reson Med 44:201–207, 2000. © 2000 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/1522-2594(200008)44:2<201::AID-MRM6>3.0.CO;2-5