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Structure and pharmacology of swelling-sensitive chloride channels, ICl,swell
Since several years, the interest for chloride channels and more particularly for the enigmatic swelling‐activated chloride channel (ICl,swell) is increasing. Despite its well‐characterized electrophysiological properties, the ICl,swell structure and pharmacology are not totally elucidated. These ch...
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Published in: | Fundamental & clinical pharmacology 2003-10, Vol.17 (5), p.539-553 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Since several years, the interest for chloride channels and more particularly for the enigmatic swelling‐activated chloride channel (ICl,swell) is increasing. Despite its well‐characterized electrophysiological properties, the ICl,swell structure and pharmacology are not totally elucidated. These channels are involved in a variety of cell functions, such as cardiac rhythm, cell proliferation and differentiation, cell volume regulation and cell death through apoptosis. This review will consider different aspects regarding structure, electrophysiological properties, pharmacology, modulation and functions of these swelling‐activated chloride channels. |
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ISSN: | 0767-3981 1472-8206 |
DOI: | 10.1046/j.1472-8206.2003.00197.x |