MOLECULAR GENETICS OF MYCOBACTERIUM TUBERCULOSIS PATHOGENESIS

Tuberculosis (TB) has afflicted humankind throughout history. Approximately one third of the world's population is currently infected with Mycobacterium tuberculosis and nearly two million people die of TB annually. Although much has been learned about the structure of the tubercle bacillus, th...

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Bibliographic Details
Published in:Annual review of microbiology 2003-01, Vol.57 (1), p.517-549
Main Authors: Clark-Curtiss, Josephine E, Haydel, Shelley E
Format: Article
Language:English
Subjects:
Bacteria
Biological and medical sciences
Epidemiology
Fundamental and applied biological sciences. Psychology
gene expression
Gene Expression Regulation, Bacterial
Genetics
Genome, Bacterial
genomics
Genomics - methods
Humans
Microbiology
Molecular Biology
Molecules
mutagenesis
Mutagenesis, Insertional - methods
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - metabolism
Mycobacterium tuberculosis - pathogenicity
Mycology
Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
Pathogens
Physiology
proteomics
Proteomics - methods
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Tuberculosis
Tuberculosis - microbiology
Virology
Virulence
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Summary:Tuberculosis (TB) has afflicted humankind throughout history. Approximately one third of the world's population is currently infected with Mycobacterium tuberculosis and nearly two million people die of TB annually. Although much has been learned about the structure of the tubercle bacillus, the epidemiology of TB, the physiological and immunological responses of the host to infection, and the physiology of M. tuberculosis in laboratory broth cultures, much of the basic biology of M. tuberculosis in its natural setting (the infected human) remains to be elucidated. Within the past decade, there have been remarkable advances in the development of genetic and molecular biological tools with which to study M. tuberculosis . This review discusses the approaches that have been employed and the progress that has been made in discovering how M. tuberculosis has achieved its prowess as a successful pathogen.
ISSN:0066-4227
1545-3251
DOI:10.1146/annurev.micro.57.030502.090903