Health promoting compounds in vegetables and fruits: A systematic approach for identifying plant components with impact on human health

Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicit...

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Bibliographic Details
Published in:Trends in food science & technology 2004-07, Vol.15 (7), p.384-393
Main Authors: Brandt, K, Christensen, L.P, Hansen-Møller, J, Hansen, S.L, Haraldsdottir, J, Jespersen, L, Purup, S, Kharazmi, A, Barkholt, V, Frøkiær, H, Kobæk-Larsen, M
Format: Article
Language:English
Subjects:
bioactive properties
Biological and medical sciences
food composition
Food industries
Fruit and vegetable industries
fruits (food)
Fundamental and applied biological sciences. Psychology
health promotion
phytochemicals
plant-based foods
research methods
screening
vegetables
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Summary:Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicity at high concentrations or other bioactivity; and 1.3, presence in healthy foods. Step 2 is testing for minimum criteria defining health-promoting compounds: 2.1, positive or biphasic (“hormesis”) responses in bioassay; 2.2, human tissue concentrations corresponding to beneficial effects in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats.
ISSN:0924-2244
1879-3053
DOI:10.1016/j.tifs.2003.12.003