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Usefulness of lipids, lipoprotein(a) and fibrinogen measurements in identifying subjects at risk of occlusive complications following vascular and endovascular surgery
The study was designed to establish the usefulness of measuring lipoprotein(a) [Lp(a)], total cholesterol, triglycerides, low-density lipoprotein [LDL]-cholesterol, high-density lipoprotein [HDL]-cholesterol, total-to-HDL-cholesterol ratio and fibrinogen in identifying subjects at risk of occlusive...
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| Published in: | Scandinavian journal of clinical and laboratory investigation 1998, Vol.58 (6), p.497-504 |
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| cited_by | cdi_FETCH-LOGICAL-c430t-d12220781daca7b1297de72b9b3582911a9c8bbdc06537c7208486956eaa364e3 |
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| cites | cdi_FETCH-LOGICAL-c430t-d12220781daca7b1297de72b9b3582911a9c8bbdc06537c7208486956eaa364e3 |
| container_end_page | 504 |
| container_issue | 6 |
| container_start_page | 497 |
| container_title | Scandinavian journal of clinical and laboratory investigation |
| container_volume | 58 |
| creator | G Lippi, G F Veraldi, V Dorucci, R Dusi, O Ruzzenente, C Brentegani, G Guidi, C Cordiano |
| description | The study was designed to establish the usefulness of measuring lipoprotein(a) [Lp(a)], total cholesterol, triglycerides, low-density lipoprotein [LDL]-cholesterol, high-density lipoprotein [HDL]-cholesterol, total-to-HDL-cholesterol ratio and fibrinogen in identifying subjects at risk of occlusive complications following vascular and endovascular surgery, including primary successful ileofemoral percutaneous transluminal angioplasty, infrainguinal and aortic bypass graft and carotid endarterectomy. A total of 68 volunteers subjected to vascular and endovascular surgery were recruited to the study. Six months after successful interventions, no occlusive complications verified by angiography were observed in 45 patients (66%; No-restenosis group), whereas significant restenosis or reocclusion occurred in 23 patients (34%; Restenosis group). Significant lower concentrations of Lp(a) (p=0.032), total cholesterol (p |
| doi_str_mv | 10.1080/00365519850186300 |
| format | article |
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A total of 68 volunteers subjected to vascular and endovascular surgery were recruited to the study. Six months after successful interventions, no occlusive complications verified by angiography were observed in 45 patients (66%; No-restenosis group), whereas significant restenosis or reocclusion occurred in 23 patients (34%; Restenosis group). Significant lower concentrations of Lp(a) (p=0.032), total cholesterol (p<0.0001), LDL-cholesterol (p=0.001) and total-to-HDL-cholesterol ratio (p<0.0001) and higher concentrations of HDL-cholesterol (p=0.048) were observed in the No-restenosis group compared to the Restenosis group. The concentrations of triglycerides (p=0.080) and fibrinogen (p=0.510) did not differ significantly between groups. In multivariate discriminant analysis, the best predictors of restenosis or reocclusion were in decreasing order: LDL-cholesterol, Lp(a), total-to-HDL-cholesterol ratio, HDL-cholesterol and total cholesterol. A statistical difference of particular interest was observed in the overall distribution of Lp(a) concentrations between groups (p<0.0001), occlusive complications being unlikely to occur in patients with Lp(a) concentrations below 50 mg L-1. The potential interference from a concurrent acute phase response, the most common source of elevation of Lp(a) in humans, was less likely in view of the absence of differences in erythrocyte sedimentation rate between the No-restenosis and Restenosis groups (p=0.463). In conclusion, the results of the present investigation point to a definite role of the combined measurements LDL-cholesterol, Lp(a), total-to-HDL-cholesterol ratio, HDL-cholesterol and total cholesterol in the identification of subjects at risk of occlusive events following vascular and endovascular surgical procedures.</description><identifier>ISSN: 0036-5513</identifier><identifier>EISSN: 1502-7686</identifier><identifier>DOI: 10.1080/00365519850186300</identifier><identifier>PMID: 9832342</identifier><identifier>CODEN: SJCLAY</identifier><language>eng</language><publisher>Oslo: Informa UK Ltd</publisher><subject>Angioplasty, Balloon ; Aorta - surgery ; Arterial Occlusive Diseases - blood ; Arterial Occlusive Diseases - diagnosis ; Arterial Occlusive Diseases - etiology ; Biological and medical sciences ; Carotid Arteries - surgery ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Endarterectomy ; Fibrinogen - analysis ; Humans ; Lipids - blood ; Lipoprotein(a) - blood ; Medical sciences ; Postoperative Complications - blood ; Postoperative Complications - diagnosis ; Retinal Vein Occlusion - blood ; Retinal Vein Occlusion - diagnosis ; Retinal Vein Occlusion - etiology ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Vascular Diseases - surgery</subject><ispartof>Scandinavian journal of clinical and laboratory investigation, 1998, Vol.58 (6), p.497-504</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-d12220781daca7b1297de72b9b3582911a9c8bbdc06537c7208486956eaa364e3</citedby><cites>FETCH-LOGICAL-c430t-d12220781daca7b1297de72b9b3582911a9c8bbdc06537c7208486956eaa364e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1586957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9832342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>G Lippi, G F Veraldi, V Dorucci, R Dusi, O Ruzzenente, C Brentegani, G Guidi, C Cordiano</creatorcontrib><title>Usefulness of lipids, lipoprotein(a) and fibrinogen measurements in identifying subjects at risk of occlusive complications following vascular and endovascular surgery</title><title>Scandinavian journal of clinical and laboratory investigation</title><addtitle>Scand J Clin Lab Invest</addtitle><description>The study was designed to establish the usefulness of measuring lipoprotein(a) [Lp(a)], total cholesterol, triglycerides, low-density lipoprotein [LDL]-cholesterol, high-density lipoprotein [HDL]-cholesterol, total-to-HDL-cholesterol ratio and fibrinogen in identifying subjects at risk of occlusive complications following vascular and endovascular surgery, including primary successful ileofemoral percutaneous transluminal angioplasty, infrainguinal and aortic bypass graft and carotid endarterectomy. A total of 68 volunteers subjected to vascular and endovascular surgery were recruited to the study. Six months after successful interventions, no occlusive complications verified by angiography were observed in 45 patients (66%; No-restenosis group), whereas significant restenosis or reocclusion occurred in 23 patients (34%; Restenosis group). Significant lower concentrations of Lp(a) (p=0.032), total cholesterol (p<0.0001), LDL-cholesterol (p=0.001) and total-to-HDL-cholesterol ratio (p<0.0001) and higher concentrations of HDL-cholesterol (p=0.048) were observed in the No-restenosis group compared to the Restenosis group. The concentrations of triglycerides (p=0.080) and fibrinogen (p=0.510) did not differ significantly between groups. In multivariate discriminant analysis, the best predictors of restenosis or reocclusion were in decreasing order: LDL-cholesterol, Lp(a), total-to-HDL-cholesterol ratio, HDL-cholesterol and total cholesterol. A statistical difference of particular interest was observed in the overall distribution of Lp(a) concentrations between groups (p<0.0001), occlusive complications being unlikely to occur in patients with Lp(a) concentrations below 50 mg L-1. The potential interference from a concurrent acute phase response, the most common source of elevation of Lp(a) in humans, was less likely in view of the absence of differences in erythrocyte sedimentation rate between the No-restenosis and Restenosis groups (p=0.463). In conclusion, the results of the present investigation point to a definite role of the combined measurements LDL-cholesterol, Lp(a), total-to-HDL-cholesterol ratio, HDL-cholesterol and total cholesterol in the identification of subjects at risk of occlusive events following vascular and endovascular surgical procedures.</description><subject>Angioplasty, Balloon</subject><subject>Aorta - surgery</subject><subject>Arterial Occlusive Diseases - blood</subject><subject>Arterial Occlusive Diseases - diagnosis</subject><subject>Arterial Occlusive Diseases - etiology</subject><subject>Biological and medical sciences</subject><subject>Carotid Arteries - surgery</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Endarterectomy</subject><subject>Fibrinogen - analysis</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Lipoprotein(a) - blood</subject><subject>Medical sciences</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - diagnosis</subject><subject>Retinal Vein Occlusion - blood</subject><subject>Retinal Vein Occlusion - diagnosis</subject><subject>Retinal Vein Occlusion - etiology</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Vascular Diseases - surgery</subject><issn>0036-5513</issn><issn>1502-7686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNp9UU1v1DAQtRCoLIUfwAHJB4RAYsEfSeyoXFDFl1SJCz1HE3uy9eLYi5202l_E38RhlyKE1NOMZ957M89DyFPO3nCm2VvGZFPXvNU147qRjN0jK14zsVaNbu6T1dJfF4B8SB7lvGXlLXV1Qk5aLYWsxIr8vMw4zD5gzjQO1Luds_n1EuMuxQldeAmvKARLB9cnF-IGAx0R8pxwxDBl6gJ1tmRu2LuwoXnut2hKHSaaXP6-qEZj_JzdNVITx513BiYXQ6ZD9D7eLKxryGb2kH5PwmDjbaEM2mDaPyYPBvAZnxzjKbn8-OHb-ef1xddPX87fX6xNJdm0tlwIwZTmFgyonotWWVSib3tZa9FyDq3RfW8Na2qpjBJMV7pp6wYBZFOhPCUvDrrF_Y8Z89SNLhv0HgLGOXeKMcV52xYgPwBNijknHLpdciOkfcdZtxyn--84hfPsKD73I9pbxvEapf_82C_uwQ8JgnH5r3C9rKoK7N0B5sIQ0wg3MXnbTbD3Mf3hyLu2OPuHfoXgpysDCbttnFMo33uHh18Ik8Ae</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>G Lippi, G F Veraldi, V Dorucci, R Dusi, O Ruzzenente, C Brentegani, G Guidi, C Cordiano</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Usefulness of lipids, lipoprotein(a) and fibrinogen measurements in identifying subjects at risk of occlusive complications following vascular and endovascular surgery</title><author>G Lippi, G F Veraldi, V Dorucci, R Dusi, O Ruzzenente, C Brentegani, G Guidi, C Cordiano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-d12220781daca7b1297de72b9b3582911a9c8bbdc06537c7208486956eaa364e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Angioplasty, Balloon</topic><topic>Aorta - surgery</topic><topic>Arterial Occlusive Diseases - blood</topic><topic>Arterial Occlusive Diseases - diagnosis</topic><topic>Arterial Occlusive Diseases - etiology</topic><topic>Biological and medical sciences</topic><topic>Carotid Arteries - surgery</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Endarterectomy</topic><topic>Fibrinogen - analysis</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Lipoprotein(a) - blood</topic><topic>Medical sciences</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - diagnosis</topic><topic>Retinal Vein Occlusion - blood</topic><topic>Retinal Vein Occlusion - diagnosis</topic><topic>Retinal Vein Occlusion - etiology</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Vascular Diseases - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>G Lippi, G F Veraldi, V Dorucci, R Dusi, O Ruzzenente, C Brentegani, G Guidi, C Cordiano</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>G Lippi, G F Veraldi, V Dorucci, R Dusi, O Ruzzenente, C Brentegani, G Guidi, C Cordiano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of lipids, lipoprotein(a) and fibrinogen measurements in identifying subjects at risk of occlusive complications following vascular and endovascular surgery</atitle><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle><addtitle>Scand J Clin Lab Invest</addtitle><date>1998</date><risdate>1998</risdate><volume>58</volume><issue>6</issue><spage>497</spage><epage>504</epage><pages>497-504</pages><issn>0036-5513</issn><eissn>1502-7686</eissn><coden>SJCLAY</coden><abstract>The study was designed to establish the usefulness of measuring lipoprotein(a) [Lp(a)], total cholesterol, triglycerides, low-density lipoprotein [LDL]-cholesterol, high-density lipoprotein [HDL]-cholesterol, total-to-HDL-cholesterol ratio and fibrinogen in identifying subjects at risk of occlusive complications following vascular and endovascular surgery, including primary successful ileofemoral percutaneous transluminal angioplasty, infrainguinal and aortic bypass graft and carotid endarterectomy. A total of 68 volunteers subjected to vascular and endovascular surgery were recruited to the study. Six months after successful interventions, no occlusive complications verified by angiography were observed in 45 patients (66%; No-restenosis group), whereas significant restenosis or reocclusion occurred in 23 patients (34%; Restenosis group). Significant lower concentrations of Lp(a) (p=0.032), total cholesterol (p<0.0001), LDL-cholesterol (p=0.001) and total-to-HDL-cholesterol ratio (p<0.0001) and higher concentrations of HDL-cholesterol (p=0.048) were observed in the No-restenosis group compared to the Restenosis group. The concentrations of triglycerides (p=0.080) and fibrinogen (p=0.510) did not differ significantly between groups. In multivariate discriminant analysis, the best predictors of restenosis or reocclusion were in decreasing order: LDL-cholesterol, Lp(a), total-to-HDL-cholesterol ratio, HDL-cholesterol and total cholesterol. A statistical difference of particular interest was observed in the overall distribution of Lp(a) concentrations between groups (p<0.0001), occlusive complications being unlikely to occur in patients with Lp(a) concentrations below 50 mg L-1. The potential interference from a concurrent acute phase response, the most common source of elevation of Lp(a) in humans, was less likely in view of the absence of differences in erythrocyte sedimentation rate between the No-restenosis and Restenosis groups (p=0.463). In conclusion, the results of the present investigation point to a definite role of the combined measurements LDL-cholesterol, Lp(a), total-to-HDL-cholesterol ratio, HDL-cholesterol and total cholesterol in the identification of subjects at risk of occlusive events following vascular and endovascular surgical procedures.</abstract><cop>Oslo</cop><pub>Informa UK Ltd</pub><pmid>9832342</pmid><doi>10.1080/00365519850186300</doi><tpages>8</tpages></addata></record> |
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| ispartof | Scandinavian journal of clinical and laboratory investigation, 1998, Vol.58 (6), p.497-504 |
| issn | 0036-5513 1502-7686 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_1586957 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Angioplasty, Balloon Aorta - surgery Arterial Occlusive Diseases - blood Arterial Occlusive Diseases - diagnosis Arterial Occlusive Diseases - etiology Biological and medical sciences Carotid Arteries - surgery Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Endarterectomy Fibrinogen - analysis Humans Lipids - blood Lipoprotein(a) - blood Medical sciences Postoperative Complications - blood Postoperative Complications - diagnosis Retinal Vein Occlusion - blood Retinal Vein Occlusion - diagnosis Retinal Vein Occlusion - etiology Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Vascular Diseases - surgery |
| title | Usefulness of lipids, lipoprotein(a) and fibrinogen measurements in identifying subjects at risk of occlusive complications following vascular and endovascular surgery |
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