PRENATAL MATERNAL BIOCHEMISTRY PREDICTS NEONATAL BIOCHEMISTRY

Depressed (n = 45) and nondepressed (n = 47) mothers were recruited prenatally at an ultrasound clinic. Their urine samples were assayed for cortisol, catecholamines (norepinephrine, epinephrine, dopamine) and serotonin. Their urines were assayed again at the neonatal period, and their newborns'...

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Published in:International journal of neuroscience 2004-08, Vol.114 (8), p.933-945
Main Authors: FIELD, TIFFANY, DIEGO, MIGUEL, HERNANDEZ-REIF, MARIA, VERA, YANEXY, GIL, KARLA, SCHANBERG, SAUL, KUHN, CYNTHIA, GONZALEZ-GARCIA, ADOLFO
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Analysis of Variance
Behavioral psychophysiology
Biochemical Phenomena
Biochemistry
Biological and medical sciences
Catecholamines - urine
Depression
Depression - urine
Female
Fundamental and applied biological sciences. Psychology
Humans
Hydrocortisone - urine
Infant, Newborn - urine
Male
Maternal-Fetal Exchange
Medical sciences
Mood disorders
Mothers - psychology
Neurotransmission and behavior
Pregnancy - urine
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Reference Values
Regression Analysis
Serotonin - urine
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Summary:Depressed (n = 45) and nondepressed (n = 47) mothers were recruited prenatally at an ultrasound clinic. Their urine samples were assayed for cortisol, catecholamines (norepinephrine, epinephrine, dopamine) and serotonin. Their urines were assayed again at the neonatal period, and their newborns' urines were also assayed at that time. The depressed versus the nondepressed mothers showed significantly higher cortisol and norepinephrine and significantly lower dopamine levels across the pre- and postnatal assessments. At the postnatal assessment all levels had decreased except the serotonin levels for both groups. Regression analyses on the mother's postnatal biochemistry with the prenatal biochemistry entered as predictor variables showed highly significant, specific relationships between each of the catecholamines, cortisol, and serotonin. The newborn's biochemistry (except for epinephrine) was higher than the maternal biochemistry. Regression analyses on the neonatal biochemistry with the mother's prenatal biochemistry entered as predictor- variables also suggested highly significant, specific relationships. The continuity between the mother's and the newborn's neurotransmitter/-neurohormone profiles and data showing that elevated norepinephrine and cortisol predict to low birthweight and prematurity, respectively, highlight the importance of assessing these levels during pregnancy.
ISSN:0020-7454
1563-5279
1543-5245
DOI:10.1080/00207450490461305