Lipase-catalyzed ammonolysis of trimethylsilylmethyl acetate in organic solvent

Lipase could catalyze the ammonolysis of trimethylsilylmethyl acetate in organic solvents and Novozym 435 was the best biocatalyst for the reaction. The influences of some factors on the reaction were investigated. Cyclohexane, n-hexane and heptane were found to be suitable reaction media and ammoni...

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Bibliographic Details
Published in:Biocatalysis and biotransformation 2004-05, Vol.22 (3), p.183-187
Main Authors: Peng, Hua-song, Zong, Min-hua, Wang, Ju-fang, Xu, Yi-qun
Format: Article
Language:English
Subjects:
Ammonolysis
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Biotransformation
Fundamental and applied biological sciences. Psychology
Lipase
Methods. Procedures. Technologies
Microaqueous phase
Silicon atom
Trimethylsilylmethyl acetate
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Summary:Lipase could catalyze the ammonolysis of trimethylsilylmethyl acetate in organic solvents and Novozym 435 was the best biocatalyst for the reaction. The influences of some factors on the reaction were investigated. Cyclohexane, n-hexane and heptane were found to be suitable reaction media and ammonium carbamate was the best ammonium source. The optimal initial water activity, temperature and pH value were 0.55-0.75, 35°C and 6.5 respectively, under which a substrate conversion of 97.6% could be achieved after reaction for 140 h.
ISSN:1024-2422
1029-2446
DOI:10.1080/10242420410001727364