Separation studies in a continuous flow fluorous biphasic system: Proof of concept

• Published in: Journal of molecular catalysis. A, Chemical Chemical, 2004-11, Vol.221 (1), p.19-27
• Main Authors: Perperi, Evangelia, Huang, Yulin, Angeli, Panagiota, Manos, George, Cole-Hamilton, David J.
• Format: Article
• Language: English
• Subjects: Catalysis; Chemistry; Exact sciences and technology; Fluorous biphasic system; General and physical chemistry; Hydroformylation; Liquid–liquid separation; Octene; Phase behaviour; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
• ISSN: 1381-1169; 1873-314X
• DOI: 10.1016/j.molcata.2004.05.038

A proof of concept study was undertaken for the separation of the fluorous solvent from the organic reactants/products of a fluorous biphasic system, in the absence of fluorous modified Rh catalyst. Fast and efficient separation of the two phases was observed. The more polar products were present in the organic phase—i.e. the higher the simulated conversion level—the less was the leaching of the fluorous solvent in the organic phase. A proof of concept study was undertaken for the separation of the fluorous solvent from the organic reactants/products of a fluorous biphasic system, in the absence of fluorous modified Rh catalyst. Fast and efficient separation of the two phases was observed. The more polar products were present in the organic phase—i.e. the higher the simulated conversion level—the less was the leaching of the fluorous solvent in the organic phase.