Structure-activity relationship for FR901464: A versatile method for the conversion and preparation of biologically active biotinylated probes

The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2004-10, Vol.68 (10), p.2178-2182
Main Authors: Motoyoshi, H. (Tokyo Univ. (Japan)), Horigome, M, Ishigami, K, Yoshida, T, Horinouchi, S, Yoshida, M, Watanabe, H, Kitahara, T
Format: Article
Language:English
Subjects:
Biological and medical sciences
BIOTIN
Biotin - chemistry
Biotinylation
CELL CYCLE
Cell Cycle - drug effects
cell cycle inhibitor
CHEMICAL SYNTHESIS
CHEMICALS
conversion
FR901464
Fundamental and applied biological sciences. Psychology
INHIBITION
Pyrans - analysis
Pyrans - chemical synthesis
Pyrans - chemistry
Pyrans - pharmacology
Spiro Compounds - analysis
Spiro Compounds - chemical synthesis
Spiro Compounds - chemistry
Spiro Compounds - pharmacology
Structure-Activity Relationship
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Summary:The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.68.2178