Inflammatory myofibroblastic tumor in the larynx: clinicopathologic features and histogenesis

Inflammatory myofibroblastic tumor is extremely rare in the larynx and can mimic a malignant process. We present the case of a 62-year-old male who required tracheotomy due to rapidly progressive stridor. Laryngoscopy showed an exophytic, occlusive tumor located in the right true vocal cord. CT show...

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Bibliographic Details
Published in:Acta oto-laryngologica 2005-02, Vol.125 (2), p.215-219
Main Authors: Maria Guilemany, Jose, Alós, Llucia, Alobid, Isam, Bernal-Sprekelsen, Manuel, Cardesa, Antonio
Format: Article
Language:English
Subjects:
Biological and medical sciences
Humans
Inflammatory myofibroblastic tumor
Laryngeal Neoplasms - diagnostic imaging
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
larynx
Laser Therapy - methods
Male
Medical sciences
Middle Aged
Neoplasms, Muscle Tissue - diagnostic imaging
Neoplasms, Muscle Tissue - pathology
Neoplasms, Muscle Tissue - surgery
Otorhinolaryngology. Stomatology
Tomography, X-Ray Computed
Tracheotomy
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Summary:Inflammatory myofibroblastic tumor is extremely rare in the larynx and can mimic a malignant process. We present the case of a 62-year-old male who required tracheotomy due to rapidly progressive stridor. Laryngoscopy showed an exophytic, occlusive tumor located in the right true vocal cord. CT showed an expansive mass measuring 2×2×1.3 cm3 and occupying the anterior commissure, with glottic progression to the right true vocal cord. The tumor was completely resected with a CO2 laser via a transoral approach. Histologic examination demonstrated extensive ulceration with the presence of granulation tissue. The specimen was mainly composed of spindle cells arranged in a fasciculated pattern with a myxoid background and focal hyalinization. Immunohistochemical studies revealed positivity of spindle cells to vimentin, muscle-specific actin and smooth muscle actin. The patient showed no evidence of disease 24 months after surgery.
ISSN:0001-6489
1651-2251
DOI:10.1080/00016480410022796