Latex Agglutination Test for Monitoring Antibodies to Avian Influenza Virus Subtype H5N1

A latex agglutination test (LAT) based on polystyrene beads sensitized with inactivated avian influenza virus H5N1 particles was developed. Compared with the hemagglutination inhibition test, the sensitivity and specificity of the LAT were 88.8 and 97.6%, respectively, in detecting 830 serum samples...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005-04, Vol.43 (4), p.1953-1955
Main Authors: Xu, Xiaojuan, Jin, Meilin, Yu, Zhengjun, Li, Hongchao, Qiu, Dexin, Tan, Yadi, Chen, Huanchun
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - blood
Avian influenza virus
Biological and medical sciences
Chick Embryo
Chickens
Fundamental and applied biological sciences. Psychology
Infectious diseases
Influenza A virus - immunology
Influenza A Virus, H5N1 Subtype
Influenza in Birds - prevention & control
Influenza in Birds - virology
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Latex Fixation Tests
Medical sciences
Microbiology
Microspheres
Miscellaneous
Polystyrenes
Poultry Diseases - prevention & control
Poultry Diseases - virology
Reproducibility of Results
Sensitivity and Specificity
Virion - immunology
Virology
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Description
Summary:A latex agglutination test (LAT) based on polystyrene beads sensitized with inactivated avian influenza virus H5N1 particles was developed. Compared with the hemagglutination inhibition test, the sensitivity and specificity of the LAT were 88.8 and 97.6%, respectively, in detecting 830 serum samples from vaccinated chickens. The test has application potential in field practice.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.43.4.1953-1955.2005