Investigations into the C-deuteriation of enol acetates derived from aryl alkyl ketones

Results are reported on the regioselective C‐deuteriation of a series of enol acetates (derived from the aryl alkyl ketones) using molecular deuterium as the D‐source and palladium‐on‐barium sulphate as the mediator. The results presented highlight potential problems associated with the deuteriation...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2005-04, Vol.48 (5), p.337-352
Main Authors: Buksha, Svitlana, Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Suggate, Michael J., Weerasooriya, Neluka
Format: Article
Language:English
Subjects:
Chemistry
deuteriation
deuterium
enol acetates
Exact sciences and technology
hydrogenation
Labelled compounds chemistry
Organic chemistry
palladium and reduction
Reactivity and mechanisms
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Summary:Results are reported on the regioselective C‐deuteriation of a series of enol acetates (derived from the aryl alkyl ketones) using molecular deuterium as the D‐source and palladium‐on‐barium sulphate as the mediator. The results presented highlight potential problems associated with the deuteriation of enol acetates. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.928