Innovative treatment programs against cancer: II. nuclear factor-κB (NF-κB) as a molecular target

Nuclear factor-κB (NF-κB) activity affects cell survival and determines the sensitivity of cancer cells to cytotoxic agents as well as to ionizing radiation. Preventing the protective function of NF-κB may result in chemo- and radio-sensitization of cancer cells. Therefore, NF-κB has emerged as one...

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Bibliographic Details
Published in:Biochemical pharmacology 1999, Vol.57 (1), p.9-17
Main Authors: Waddick, Kevin G., Uckun, Fatih M.
Format: Article
Language:English
Subjects:
Antineoplastic agents
apoptosis
Biological and medical sciences
cancer
General aspects
Medical sciences
molecular target
Pharmacology. Drug treatments
rational drug design
signal transduction
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Summary:Nuclear factor-κB (NF-κB) activity affects cell survival and determines the sensitivity of cancer cells to cytotoxic agents as well as to ionizing radiation. Preventing the protective function of NF-κB may result in chemo- and radio-sensitization of cancer cells. Therefore, NF-κB has emerged as one of the most promising molecular targets in rational drug design efforts of translational cancer research programs.
ISSN:0006-2952
1873-2968
DOI:10.1016/S0006-2952(98)00224-X