AEROSOLIZED HYALURONAN LIMITS AIRSPACE ENLARGEMENT IN A MOUSE MODEL OF CIGARETTE SMOKE-INDUCED PULMONARY EMPHYSEMA

This study was designed to determine if aerosolized hyaluronan (HA) could prevent airspace enlargement and elastic fiber injury in a mouse model of cigarette smoke-induced pulmonary emphysema. Compared to untreated smoked controls, HA-treated animals showed statistically significant reductions in me...

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Bibliographic Details
Published in:Experimental lung research 2005-05, Vol.31 (4), p.417-430
Main Authors: Cantor, Jerome O., Cerreta, Joseph M., Ochoa, Marcos, Ma, Shuren, Chow, Tony, Grunig, Gabriele, Turino, Gerard M.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - therapeutic use
Administration, Inhalation
Aerosols
Animals
Biological and medical sciences
Bronchoalveolar Lavage Fluid - chemistry
Bronchoalveolar Lavage Fluid - cytology
Cell Count
cigarette smoke
Desmosine - metabolism
Disease Models, Animal
elastase
elastic fibers
Elastic Tissue - drug effects
Elastic Tissue - metabolism
Elastic Tissue - pathology
emphysema
Female
hyaluronan
Hyaluronic Acid - therapeutic use
Isodesmosine - metabolism
Lung - drug effects
Lung - metabolism
Lung - pathology
Macrophages, Alveolar - drug effects
Macrophages, Alveolar - pathology
Medical sciences
Mice
Mice, Inbred DBA
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - metabolism
Pulmonary Alveoli - pathology
Pulmonary Emphysema - chemically induced
Pulmonary Emphysema - drug therapy
Pulmonary Emphysema - pathology
Smoking - adverse effects
Tobacco, tobacco smoking
Toxicology
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Summary:This study was designed to determine if aerosolized hyaluronan (HA) could prevent airspace enlargement and elastic fiber injury in a mouse model of cigarette smoke-induced pulmonary emphysema. Compared to untreated smoked controls, HA-treated animals showed statistically significant reductions in mean linear intercept (54 versus 65 μm; P < .001) and elastic fiber breakdown products (desmosine and isodesmosine) in bronchoalveolar lavage fluid (0.3 versus 7.0 ng mL; P < .05). As in previous studies, the aerosolized HA showed preferential binding to elastic fibers, suggesting that it may protect them from injury. These findings support further investigation of the potential use of HA as a treatment for pulmonary emphysema.
ISSN:0190-2148
1521-0499
DOI:10.1080/01902140590918669