High Frequency of Gastric Colonization with Multiple Helicobacter pylori Strains in Venezuelan Subjects

Multiple Helicobacter pylori strains may colonize an individual host. Using enzyme-linked immunosorbent assay and line probe assay (LiPA) techniques, we analyzed the prevalence of mixed H. pylori colonization in 127 subjects from Venezuela, a country of high H. pylori prevalence, from three regions...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005-06, Vol.43 (6), p.2635-2641
Main Authors: Ghose, C, Perez-Perez, G. I, van Doorn, L. J, Domínguez-Bello, M. G, Blaser, M. J
Format: Article
Language:English
Subjects:
African Continental Ancestry Group
Antigens, Bacterial - genetics
Asian Continental Ancestry Group
Bacterial Proteins - genetics
Bacteriology
Biological and medical sciences
European Continental Ancestry Group
Fundamental and applied biological sciences. Psychology
Gastric Mucosa - microbiology
Gastritis - microbiology
Genotype
Helicobacter Infections - epidemiology
Helicobacter Infections - ethnology
Helicobacter Infections - microbiology
Helicobacter pylori - classification
Helicobacter pylori - genetics
Helicobacter pylori - isolation & purification
Humans
Indians, South American
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Prevalence
Venezuela - epidemiology
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Summary:Multiple Helicobacter pylori strains may colonize an individual host. Using enzyme-linked immunosorbent assay and line probe assay (LiPA) techniques, we analyzed the prevalence of mixed H. pylori colonization in 127 subjects from Venezuela, a country of high H. pylori prevalence, from three regions representing different population groups: the Andes (Merida), where Caucasian mestizos predominate, a major city near the coast (Caracas), where Amerindian-Caucasian-African mestizos predominate, and an Amazonian community (Puerto Ayacucho), where Amerindians predominate and mestizos reflect Amerindian and Caucasian ancestry. Among 121 H. pylori-positive persons, the prevalence of cagA-positive strains varied from 50% (Merida) to 86% (Puerto Ayacucho) by LiPA. Rates of mixed colonization also varied, as assessed by LiPA of the vacA s (mean, 49%) and m (mean, 26%) regions. In total, 55% of the individuals had genotypic evidence of mixed colonization. vacA s1c, a marker of Amerindian (East Asian) origin, was present in all three populations, especially from Puerto Ayacucho (86%). These results demonstrate the high prevalence of mixed colonization and indicate that the H. pylori East Asian vacA genotype has survived in all three populations tested.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.43.6.2635-2641.2005