Cryptococcal Antigen Test Revisited: Significance for Cryptococcal Meningitis Therapy Monitoring in a Tertiary Chinese Hospital

For a total of 29 non-human immunodeficiency virus 1 cryptococcal meningitis cases, titer changes in the latex agglutination test before and after therapy were reviewed along with clinical manifestations, laboratory findings, and therapy regimens. The cryptococcal antigen titer decreased for every c...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005-06, Vol.43 (6), p.2989-2990
Main Authors: Lu, Hongzhou, Zhou, Yingjie, Yin, Youkuan, Pan, Xiaozhang, Weng, Xinhua
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antifungal Agents - therapeutic use
Antigens, Fungal - analysis
Biological and medical sciences
Child
China
Cryptococcus - drug effects
Cryptococcus - immunology
Cryptococcus - isolation & purification
Culture Media
Female
Fundamental and applied biological sciences. Psychology
Hospitals, University
Humans
Infectious diseases
Latex Fixation Tests
Male
Medical sciences
Meningitis, Cryptococcal - diagnosis
Meningitis, Cryptococcal - drug therapy
Meningitis, Cryptococcal - microbiology
Microbiology
Middle Aged
Mycology
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Description
Summary:For a total of 29 non-human immunodeficiency virus 1 cryptococcal meningitis cases, titer changes in the latex agglutination test before and after therapy were reviewed along with clinical manifestations, laboratory findings, and therapy regimens. The cryptococcal antigen titer decreased for every case after therapy and was correlated to fungal clearance as defined by fungus smear and/or culture. However, cryptococcal antigen can remain at low titers for long periods of time after therapy, even when fungus smears and/or cultures become negative.
ISSN:0095-1137
1098-660X
DOI:10.1128/jcm.43.6.2989-2990.2005