Mycobacterial Lipomannan Induces Matrix Metalloproteinase-9 Expression in Human Macrophagic Cells through a Toll-Like Receptor 1 (TLR1)/TLR2- and CD14-Dependent Mechanism

Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are ind...

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Bibliographic Details
Published in:Infection and Immunity 2005-10, Vol.73 (10), p.7064-7068
Main Authors: Elass, Elisabeth, Aubry, Lae̊titia, Masson, Maryse, Denys, Agnès, Guérardel, Yann, Maes, Emmanuel, Legrand, Dominique, Mazurier, Joe̊l, Kremer, Laurent
Format: Article
Language:English
Subjects:
Antibodies - pharmacology
Biochemistry, Molecular Biology
Biological and medical sciences
Cells, Cultured
Down-Regulation
Fundamental and applied biological sciences. Psychology
Host Response and Inflammation
Humans
Life Sciences
Lipopolysaccharide Receptors - metabolism
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Macrophages - enzymology
Matrix Metalloproteinase 9 - genetics
Matrix Metalloproteinase 9 - metabolism
Microbiology
Mycobacterium
Mycobacterium - metabolism
Signal Transduction - drug effects
Signal Transduction - genetics
Structural Biology
Tissue Inhibitor of Metalloproteinase-1 - genetics
Transcription, Genetic - drug effects
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Summary:Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are indicative of a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent signaling mechanism. Moreover, LM was shown to down-regulate transcription of the metalloproteinase inhibitor TIMP-1, a major endogenous MMP-9 regulator.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.10.7064-7068.2005